论文：(*, corresponding)

1

Wen L^#, Tang FL^#, Hong Y, Luo SW, Wang CL, He W, Shen C, Jung JU, Xiong F, Lee DH, Zhang QG, Brann D, Kim TW, Yan R, Mei L, Xiong WC^*. VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology. J Cell Biol 195(5):765-779, 2011 (^#, co-first author)

2

Wen L^#, Lu YS^#, Zhu XH^#, Li XM, Woo RS, Chen YJ, Yin DM, Lai C, Terry AV Jr, Vazdarjanova A, Xiong WC, Mei L*. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc Natl Acad Sci U S A 107(3): 1211-1216, 2010 (#, co-first author)

3

Yu YE^#, Wen L^#, Silva J, Li Z, Head K, Sossey-Alaoui K, Pao A, Mei L, Cowell JK*. Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability. Hum Mol Genet 19(9): 1702-1711, 2010 (#, co-first author)

4

Wen L, Yang S, Zhou W, Zhang Y*, Huang P. New conotoxin SO-3 targeting N-type voltage-sensitive calcium channels. Marine Drugs 4(3): 215-227, 2006

5

Wen L, Yang S, Qiao H, Liu Z, Zhou W, Zhang Y*, Huang P. SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons. Br J Pharmacol 145(6): 728-739, 2005

6

Li L, Chen SR, Chen H, Wen L, Hittelman WN, Xie JD, Pan HL*. Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain. Cell Rep 17;15(7):1376-1383, 2016

7

Tian Y, Tang FL, Sun X, Wen L, Mei L, Tang BS, Xiong WC*. VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation. Mol Brain 2015 Oct 31;8(1):70. doi: 10.1186/s13041-015-0156-4

8

Chen SR, Zhu LH, Chen H, Wen L, Laumet G, Pan HL*. Increased spinal cord Na+-K+-2Cl- cotransporter-1 (NKCC1) activity contributes to impairment of synaptic inhibition in paclitaxel-induced neuropathic pain. J Biol Chem 289(45): 31111-31120, 2014

9

Ting AK, Chen Y, Wen L, Yin DM, Shen C, Tao Y, Liu X, Xiong WC, Mei L*. Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J Neurosci  31(1):15-25, 2010

10

Chen YJ, Zhang M, Yin DM, Wen L, Ting A, Wang P, Lu YS, Zhu XH, Li SJ, Wu CY, Wang XM, Lai C, Xiong WC, Mei L*, Gao TM*. ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. Proc Natl Acad Sci U S A 107(50): 21818-21823, 2010

主持课题：

1

国家自然科学基金，从离子通道及突触传递角度探讨中药青风藤镇痛的脊髓机制，2014.01-2017.12

2

教育部“新世纪优秀人才支持计划”，2014.01-2016.12

获奖：

1

2005年获第9届法国Servier研究院－中国药理学会青年药理学工作者奖