研究领域：

主要开展表观遗传学研究，研究聚焦细胞表型调控及疾病相关的染色质组蛋白密码重塑机制，筛选并鉴定关键的组蛋白修饰酶及其生物学功能。证明了menin等表观调控因子生物学功能及表观遗传学特性的多样性及重要性，深入揭示了多种表观遗传机制协同促进肿瘤的新型发病机制。

主持国家自然科学基金重大专项、面上项目等10余项科学基金，发表SCI论文30余篇，其中包括在Nature Communications、PNAS、J Hepatol、Oncogene、J Biol Chem等权威SCI刊物发表18篇通讯作者论文，获授权专利3项。获得福建省杰出青年基金，入选“新世纪百千万人才工程”福建省级人选、福建省百千万领军人才、福建省高等学校新世纪优秀人才支持计划，担任Cancer Res、J pathology、J Endocrinology等多个SCI杂志审稿人。

学习经历：

1994~1999：白求恩医科大学预防医学 医学学士；

1999~2004：吉林大学白求恩医学部放射医学 医学博士；

工作经历：

2002~2004：吉林大学白求恩医学部 助教

2004~2006：南京大学生命科学学院 生物化学与分子生物学 博士后

2006~2011：皇冠hg0086客户端  副教授

2011~2016：皇冠hg0086客户端 教授

2016~至今：皇冠hg0086客户端 特聘教授

代表性成果：

1. Huan Qiu^#, Bang-Ming Jin^#, Zhan-Feng Wang, Bin Xu, Qi-Fan Zheng, Li Zhang, Ling-Yu Zhu, Shuang Shi, Jun-Bo Yuan, Xiao Lin, Shu-Bin Gao, Guang-Hui Jin^*. MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response. Nature Communications. 2020.Feb.21；11(1009), doi: 10.1038/s41467-020-14614-4.

2. Zhan-Feng Wang, Xin-Yu Hong, Ling-Yu Zhu, Li Zhang, Huan Qiu, Yuan-Yuan Zhang, Ming-Cheng Yuan, Xing-Li Zhao, Qi-Fan Zheng^*, Guang-Hui Jin^*. Abnormal expression of menin predicts the pathogenesis and poor prognosis of adult gliomas. Cancer Gene Therapy. 2019 Aug 06. doi: 10.1038/s41417-019-0127-5.

3. Qi-Fan Zheng^#, Bin Xu^#*, Hui-Min Wang, Li-Hong Ding, Jin-Yang Liu, Ling-Yu Zhu, Huan Qiu, Li Zhang, Guang-Yi Ni, Jing Ye, Shu-Bin Gao,Guang-Hui Jin^*. Epigenetic alterations contribute to promoter activity of imprinting gene IGF2. BBA - Gene Regulatory Mechanisms. 2018 Feb;1861(2):117-124.

4. Gao SB^#, Li KL^#, Qiu H, Zhu LY, Pan CB, Zhao Y, Wei SH, Shi S, Jin GH^*, Xue LX^*. Enhancingchemotherapysensitivity by targetingPcGvia the ATM/p53pathway.Am J Cancer Res. 2017 Sep 15;7(9):1874-1883.

5. Zheng QF^#, Wang HM^#, Wang ZF, Liu JY, Zhang Q, Zhang L, Lu YH, You H, Jin GH^*.Reprogramming of histone methylation controls the differentiation of monocytes into macrophages.The FEBS Journal.2017 May 2;284(9):1309-1323.

6. Gao Z, Zhang L, Xie W, Wang S, Bao X, Guo Y, Zhang H, Hu Q, Chen Y, Wang Z, Xue M*, Jin G*. Male Men1 heterozygous mice exhibit fasting hyperglycemia in the early stage of MEN1. Journal of Endocrinology. 2016 Sep. 230(3):347-55.

7. Matkar S^#, Sharma P^#, Gao S, Gurung B, Katona BW, Liao J, Muhammad AB, Kong XC, Wang L, Jin G, Dang CV, Hua X^*. An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc Axis.Cancer Cell.2015 Oct 12;28(4):472-85.

8. Gao SB^#, Sun SL^#, Zheng QL, Zhang L, Zhu Y, Jin GH*, Xue L-X*. Genetic alteration and misexpression of Polycomb group genes in hepatocellular carcinoma.Am J Cancer Res. 2015 Oct;5(10):2969-2979.

9. Gao SB, Zheng QF, Xu B, Pan CB, Li KL, Zhao Y, Zheng QL, Lin X, Xue LX, Jin GH^*. EZH2 represses target genes through H3K27-dependent and H3K27-independent mechanisms in hepatocellular carcinoma. Mol Cancer Res. 2014 Oct;12(10):1388-97.

10. Gao SB^#, Xu B^#, Ding LH, Zheng Q, Zhang L, Zheng QF, Li SH, Feng ZJ, Wei J, Yin ZY, Hua X, Jin GH^*. The functional and mechanistic relatedness of the EZH2 and menin in hepatocellular carcinoma. J Hepatol. 2014 Oct;61(4):832-9.

11. Xu B^#, Li SH^#, Zheng R, Gao SB, Ding LH, Yin ZY, Lin X, Feng ZJ, Zhang S, Wang XM, Jin GH^*. Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription.Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17480-5.

12. Gurung B, Feng Z, Iwamoto DV, Thiel A, Jin G, Fan CM, Ng JM, Curran T, Hua X^*. Menin Epigenetically Represses Hedgehog Signaling in MEN1 Tumor Syndrome. Cancer Res. 2013 Apr 15;73(8):2650-2658.

13. Wu Y, Feng ZJ, Gao SB, Matkar S, Xu B, Duan HB, Lin X, Li SH, Hua X^*, Jin GH^*. Interplay between menin and K-Ras in regulating lung adenocarcinoma. J Biol Chem. 2012 Nov 16;287(47):40003-11.

14. Gao S, Feng ZJ, Xu B, Chen Y, Zheng HH, Yin P, Hua X, Jin GH*.Menin represses malignant phenotypes of melanoma through regulating multiple pathways. J Cell Mol Med. 2011 Nov;15(11):2353-63.

15. Xu B^#, Zeng DQ^#, Wu Y, Zheng R, Gu L, Lin X, Hua X, Jin GH^*. Tumor suppressor menin represses Paired box gene 2 expression via Wilms' tumor suppressor protein-Polycomb group complex. J Biol Chem. 2011 Apr 22;286(16):13937-44.

16. Feng ZJ, Gao SB, Wu Y, Xu XF, Hua X^*,Jin GH^*. Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP beta/zeta signaling by menin. Oncogene. 2010 Sep 30;29(39):5416-26.

17. Gao SB^#, Feng ZJ^#, Xu B, Wu Y, Yin P, Yang Y, Hua X^*, GH Jin^*. Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin. Oncogene. 2009 Nov 19;28(46):4095-104.

主持过的重要课题：

1. TrxG及SWI/SNF协同调控肺癌治疗抗性产生的染色质组蛋白重塑机制，国家自然科学基金-促进海峡两岸科技合作联合基金，U1605224，2017/01-2020/12；

2. 多基因协同诱导的神经内分泌肺癌小鼠遗传模型建立，国家自然科学基金面上项目，81572778，2016/01-2019/12；

3. menin促进肝癌恶性表型的组蛋白甲基化机制研究，国家自然科学基金面上项目，81272719，2013/01-2016/12；

4. menin调控肝炎恶性转化的信号网络与组蛋白修饰机制，国家自然科学基金重大研究计划，91229111，2013/01-2015/12；

5. 抑癌基因 menin调控的多效生长因子通路与肺癌发生，国家自然科学基金面上项目，81071926，2011/01-2013/12；

6. BMK1/ERK5信号通路激活与肿瘤辐射抗性关系探讨, 国家自然科学基金青年基金, 30701003，2008/01-2010/12；

7. menin调控的组蛋白甲基化修饰特性与肿瘤发生关系研究，福建省杰出青年基金，2011J06016，2011/01-2014/12；
   
   
   

已授权的专利：

1. 人纤溶酶原Kringle5短肽、其药物组合物、用途和编码该种多肽的多核苷酸，专利号：ZL 201010179925.9，专利公告日2014-05-28；

2. 人纤溶酶原Kringle5多克隆抗体及其制备方法及应用，专利号： ZL 2009 1 0111114.2，专利公告日2013-02-06；

3. RGD修饰的人纤溶酶原K5及其制备方法与应用，专利号：ZL 2009 1 0112480.X，专利公布日2011-11-16；

主要获奖/荣誉称号：

1. 2016年获福建省第二批百千万工程领军人才

2. 2011年获“福建省杰出青年基金”

3. 2011年度入选“福建省高等学校新世纪优秀人才支持计划”

4. 2008年“新世纪百千万人才工程” 福建省级人选

所有论文列表

1. Huan Qiu^#, Bang-Ming Jin^#, Zhan-Feng Wang, Bin Xu, Qi-Fan Zheng, Li Zhang, Ling-Yu Zhu, Shuang Shi, Jun-Bo Yuan, Xiao Lin, Shu-Bin Gao, Guang-Hui Jin*. MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response. Nature Communications. 2020.Feb.21；11(1009), DOI: 10.1038/s41467-020-14614-4. PMCID: PMC7035285.

2. Zhan-Feng Wang, Xin-Yu Hong, Ling-Yu Zhu, Li Zhang, Huan Qiu, Yuan-Yuan Zhang, Ming-Cheng Yuan, Xing-Li Zhao, Qi-Fan Zheng*, Guang-Hui Jin*. Abnormal expression of menin predicts the pathogenesis and poor prognosis of adult gliomas. Cancer Gene Therapy. 2019 Aug 06. DOI: 10.1038/s41417-019-0127-5.PMID: 31383953.

3. Qi-Fan Zheng^#, Bin Xu^#*, Hui-Min Wang, Li-Hong Ding, Jin-Yang Liu, Ling-Yu Zhu, Huan Qiu, Li Zhang, Guang-Yi Ni, Jing Ye, Shu-Bin Gao, Guang-Hui Jin*. Epigenetic alterations contribute to promoter activity of imprinting gene IGF2. BBA - Gene Regulatory Mechanisms. 2018 Feb;1861(2):117-124. DOI:10.1016/j.bbagrm.2017.12.007PMID:29413895

4. Gao SB^#, Li KL^#, Qiu H, Zhu LY, Pan CB, Zhao Y, Wei SH, Shi S, Jin GH*, Xue LX*. Enhancing chemotherapy sensitivity by targeting PcG via the ATM/p53 pathway.Am J Cancer Res. 2017 Sep 15;7(9):1874-1883. PMID:28979810 PMCID:PMC5622222

5. Zheng QF^#, Wang HM^#, Wang ZF, Liu JY, Zhang Q, Zhang L, Lu YH, You H, Jin GH*. Reprogramming of histone methylation controls the differentiation of monocytes into macrophages. The FEBS Journal. 2017 May 2;284(9):1309-1323. DOI:10.1111/febs.14060 PMID:28304152

6. Gao Z, Zhang L, Xie W, Wang S, Bao X, Guo Y, Zhang H, Hu Q, Chen Y, Wang Z, Xue M*, Jin G*. Male Men1 heterozygous mice exhibit fasting hyperglycemia in the early stage of MEN1. Journal of Endocrinology. 2016 Sep. 230(3):347-55. DOI:10.1530/JOE-16-0090 PMID:27432891

7. Matkar S^#, Sharma P^#, Gao S, Gurung B, Katona BW, Liao J, Muhammad AB, Kong XC, Wang L, Jin G, Dang CV, Hua X*. An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc Axis. Cancer Cell. 2015 Oct 12;28(4):472-85. DOI:10.1016/j.ccell.2015.09.005 PMID:26461093 PMCID:PMC4748715

8. Shu-Bin Gao^#, Shi-Long Sun^#, Qi-Lin Zheng, Li Zhang, Yuequan Zhu, Guang-Hui Jin*, Li-Xiang Xue*. Genetic alteration and misexpression of Polycomb group genes in hepatocellular carcinoma. Am J Cancer Res. 2015 Oct;5(10):2969-2979. PMID:26693053 PMCID:PMC4656724

9. Gao SB, Zheng QF, Xu B, Pan CB, Li KL, Zhao Y, Zheng QL, Lin X, Xue LX, Jin GH^*. EZH2 represses target genes through H3K27-dependent and H3K27-independent mechanisms in hepatocellular carcinoma. Mol Cancer Res. 2014 Oct;12(10):1388-97. DOI:10.1158/1541-7786.MCR-14-0034 PMID:24916103

10. Gao SB^#, Xu B^#, Ding LH, Zheng Q, Zhang L, Zheng QF, Li SH, Feng ZJ, Wei J, Yin ZY, Hua X, Jin GH^*.The functional and mechanistic relatedness of the EZH2 and menin in hepatocellular carcinoma. J Hepatol. 2014 Oct;61(4):832-9.DOI:10.1016/j.jhep.2014.05.015 PMID:24845612

11. Xu B^#, Li SH^#, Zheng R, Gao SB, Ding LH, Yin ZY, Lin X, Feng ZJ, Zhang S, Wang XM, Jin GH^*. Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription.Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17480-5. DOI:10.1073/pnas.1312022110 PMID:24101467 PMCID:PMC3808599

12. Gurung B, Feng Z, Iwamoto DV, Thiel A, Jin G, Fan CM, Ng JM, Curran T, Hua X^*. Menin Epigenetically Represses Hedgehog Signaling in MEN1 Tumor Syndrome. Cancer Res. 2013 Apr 15;73(8):2650-2658.DOI:10.1158/0008-5472.CAN-12-3158 PMID:23580576PMCID:PMC4100916

13. Lin J^#, Li H^#, Yang M, Ren J, Huang Z, Han F, Huang J, Ma J, Zhang D, Zhang Z, Wu J, Huang D, Qiao M, Jin G, Wu Q, Huang Y, Du J^*, Han J^*. A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development. Cell Rep. 2013.1.01, 3(1):200~210.DOI:10.1016/j.celrep.2012.12.012 PMID:23333278

14. Feng ZJ, Gurung B, Jin GH, Yang XL, Hua XX^*. SUMO modification of menin. Am J Cancer Res. 2013;3(1):96-106.PMID:23359867PMCID:PMC3555195

15. Wu Y, Feng ZJ, Gao SB, Matkar S, Xu B, Duan HB, Lin X, Li SH, Hua X^*, Jin GH^*. Interplay between menin and K-Ras in regulating lung adenocarcinoma. J Biol Chem. 2012 Nov 16;287(47):40003-11. DOI:10.1074/jbc.M112.382416 PMID:23027861 PMCID:PMC3501031

16. Jiang W, Jin G, Ma D, Wang F, Fu T, Chen X, Chen X, Jia K, Marikar FM, Hua Z^*. Modification of Cyclic NGR Tumor Neovasculature-Homing Motif Sequence to Human Plasminogen Kringle 5 Improves Inhibition of Tumor Growth. PLoS One. 2012 May 10;7(5):e37132.DOI:10.1371/journal.pone.0037132 PMID:22590653PMCID:PMC3349653

17. Gao S, Feng ZJ, Xu B, Chen Y, Zheng HH, Yin P, Hua X, Jin GH^*. Menin represses malignant phenotypes of melanoma through regulating multiple pathways.J Cell Mol Med. 2011 Nov;15(11):2353-63. DOI:10.1111/j.1582-4934.2010.01222.x PMID:21129151PMCID:PMC3822947

18. Xu B^#, Zeng DQ^#, Wu Y, Zheng R, Gu L, Lin X, Hua X, Jin GH^*. Tumor suppressor menin represses Paired box gene 2 expression via Wilms' tumor suppressor protein-Polycomb group complex.J Biol Chem. 2011 Apr 22;286(16):13937-44. DOI:10.1074/jbc.M110.197830 PMID:21378168PMCID:PMC3077594

19. Zhang XH^*, Zeng D, Zhang L, Zhu H, Jin GH, Xie Z^*, Chen X, Kang J, Zheng L. Low cytotoxicity porous Nd(2)(SiO(4))(3) nanoparticles with near infrared excitation and emission. Nanotechnology. 2011 May 6;22(18):185703. DOI:10.1088/0957-4484/22/18/185703 PMID:21427468

20. Wang Y, Guo Z, Ge Q, Wang E, Zhang X, Jin G^*. Preparation and characterization of RGD tumor homing peptide modified Plasminogen K5. Biotechnol Appl Biochem. 2010 Sep 24;57(1):17-24.DOI:10.1042/BA20100225 PMID:20718711

21. Feng ZJ, Gao SB, Wu Y, Xu XF, Hua X^*,Jin GH^*. Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP beta/zeta signaling by menin.Oncogene. 2010 Sep 30;29(39):5416-26.DOI:10.1038/onc.2010.282 PMID:20639902PMCID:PMC3007126

22. Gao SB^#, Feng ZJ^#, Xu B, Wu Y, Yin P, Yang Y, Hua X^*, GH Jin^*. Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin. Oncogene. 2009 Nov 19;28(46):4095-104. DOI:10.1038/onc.2009.273 PMID:19749796PMCID:PMC5399538

23. Li L^*, Chen C, Li J, Zhang A, Liu X, Xu B, Gao S, Jin G^* and Ma Z^*. Robust and hydrophilic polymeric films with honeycomb pattern and their cell scaffold applications. J Mater Chem. 2009, 19, 2789-2796. DOI:10.1039/B820279F

24. Gao SB^#, Hua X^*, Jin GH^*. Menin regulates endocrine diseases by controlling histone modification and gene transcription. Ann Endocrinol (Paris). 2008 Oct;69(5):426-32. DOI:10.1016/j.ando.2008.06.001 PMID:18752793

25. Jin SZ, Pan XN, Wu N, Jin GH, Liu SZ^*. Whole-body low dose irradiation promotes the efficacy of conventional radiotherapy for cancer and possible mechanisms. Dose Response. 2007 Oct 4; 5 (4):349-58.DOI:10.2203/dose-response.07-020.JinPMID:18648558PMCID:PMC2477709

26. Cao L, Du P, Jiang SH, Jin GH, Huang QL, Hua ZC^*. Enhancement of antitumor properties of TRAIL by targeted delivery to the tumor neovasculature. Mol Cancer Ther. 2008 Apr; 7(4): 851-61.DOI:10.1158/1535-7163.MCT-07-0533 PMID:18413798

27. Dong W, Li SF, Jin GH, Sun QM, Ma DY, Hua ZC^*. Efficient Gene Transfection into Mammalian Cells Mediated by Cross-linked Polyethylenimine. Int. J. Mol. Sci.2007, 8, 81-102.DOI:10.3390/i8020081

28. Ma D, Chen Y, Fang L, Jin G, Zhou B, Cao L, Ye J, Hua Z^*. Purification and characterization of RGD tumor-homing peptide conjugated human tumor necrosis factor alpha over-expressed in Escherichia coli.J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct 1;857(2): 231-9.DOI:10.1016/j.jchromb.2007.07.022 PMID:17716959

29. Jin GH, Ma DY, Wu N, Marikar FM, Jin SZ, Jiang WW, Liu Y, Hua ZC^*. Combination of human plasminogen kringle 5 with ionizing radiation significantly enhances the efficacy of antitumor effect. Int J Cancer. 2007 Dec 1;121(11):2539-46. DOI:10.1002/ijc.22708 PMID:17680563

30. Yang J,Jin G, Liu X^*, Liu S.Therapeutic effect of pEgr-IL18-B7.2 gene-radiotherapy in B16 melanoma-bearing mice. Hum Gene Ther. 2007 Apr;18(4):323-32.DOI:10.1089/hum.2006.133 PMID:17411412

31. Jia LJ, Wei DP, Sun QM, Jin GH, Li SF, Huang Y, Hua ZC^*.Tumor-targeting Salmonella typhimurium improves cyclophosphamide chemotherapy at maximum tolerated dose and low-dose metronomic regimens in a murine melanoma model. Int J Cancer. 2007 Aug 1;121(3):666-74.DOI:10.1002/ijc.22688 PMID:17397027

32. Li S^#, Dong W^#, Zong Y, Yin W, Jin G, Hu Q, Huang X, Jiang W, Hua ZC^*.Polyethylenimine-complexed Plasmid Particles Targeting Focal Adhesion Kinase Function as Melanoma Tumor Therapeutics.Mol Ther. 2007 Mar;15(3):515-23. DOI:10.1038/sj.mt.6300072PMID:17285141

33. Jin GH, Liu Y, Jin SZ, Liu XD^*, Liu SZ^*. UVB induced oxidative stress in human keratinocytes and protective effect of antioxidant agents. Radiat Environ Biophys. 2007 Mar;46(1):61-8. DOI:10.1007/s00411-007-0096-1 PMID:17279358

34. Dong W, Jin GH, Li SF, Sun QM, Ma DY, Hua ZC^*.Cross-linked Polyethylenimine as Potential DNA Vector for Gene Delivery with High Efficiency and Low Cytotoxicity. Acta Biochim Biophys Sin.2006 Nov;38(11):780-7. DOI:10.1111/j.1745-7270.2006.00220.x PMID:17091195

35. Jin GH, Jin SZ, Liu Y, Xu RM, Yang JZ, Pan XN, Liu SZ^*. Therapeutic effect of gene-therapy in combination with local X-irradiation in a mouse malignant melanoma model. Biochem Biophys Res Commun. 2005 May 13;330(3):975-81. DOI:10.1016/j.bbrc.2005.03.070PMID:15809091

36. Mu Y, Lv S, Ren X, Jin G, Liu J, Yan G, Li W, Shen J, Luo G^*. UV-B induced keratinocyte apoptosis is blocked by 2-selenium-bridged beta-cyclodextrin, a GPX mimic.J Photochem Photobiol B. 2003 Jan; 69(2003):7-12. DOI:10.1016/S1011-1344(02)00386-X PMID:12547491