研究领域：

研究髓鞘形成胶质细胞的发育以及疾病发生的分子机制。1）研究表观遗传学和染色质重塑调控髓鞘细胞（少突胶质细胞和雪旺氏细胞）分化和疾病的发生。2）研究信号通路包括G蛋白偶联受体信号对神经胶质细胞分化和再生的调控。

学习和工作经历

2006年毕业于美国Rush University 免疫与微生物专业,获博士学位  

2007年至2012年在西南医学中心从事博士后工作

代表性成果

1.  A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism. Ou Z, Ma Y, Sun Y, Zheng G, Wang S, Xing R, Chen X, Han Y, Wang J, Lu QR, Zhao TJ, Chen Y.Cell Rep. 2019 Mar 12;26(11):2984-2997.

2.  Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination. Ou Z, Sun Y, Lin L, You N, Liu X, Li H, Ma Y, Cao L, Han Y, Liu M, Deng Y, Yao L, Lu QR, Chen Y.J Neurosci. 2016 Oct 12;36(41):10560-10573.

3.  Olig2 Targets Chromatin Remodelers To Enhancers To Initiate Oligodendrocyte Differentiation. Yu Y*, Y. Chen*, B. Kim*, H. Wang, C. Zhao, X. He, L. Liu, W. Liu, L. M. N. Wu, M. Mao, J. R. Chan, J. Wu and Q. R. Lu Cell. 2013 152 1-14 (* Equal contribution)

4.  HDAC-mediated Deacetylation of NF-κB is Critical for Schwann cell Myelination. Ying Chen, Haibo Wang, Sung Ok Yoon, Xiaomei Xu, Michael Hottiger, Haesun Kim, Eric N. Olson, and Q. Richard Lu.  Nature Neuroscience. 2011 Apr;14(4):437-41.

5.  The oligodendrocyte-specific G-protein coupled receptor GPR17 is a cell intrinsic timer of myelination. Chen, Y. H. Wu, S. Wang, H. Koito, J. Li, J. Hoang, F. Ye, S. S. Escobar, A. Gow, H. A. Arnett, B. D. Trapp, N. J. Karandikar, J. Hsieh and Q. R. Lu. Nature Neuroscience. 2009 12 1398-1406

6.  The basic helix-loop-helix transcription factor olig2 is critical for reactive astrocyte proliferation after cortical injury. Chen Y, Miles DK, Hoang T, Shi J, Hurlock E, Kernie SG, Lu QR. J Neurosci. 2008 Oct 22;28(43):10983-9.