曹 彬 国家高层次青年人才 福建省“闽江学者”特聘教授、博士生导师 皇冠“南强青年拔尖A类人才” 学科（方向）：生殖生物学与生殖医学 所在系部：生殖调控与生殖健康研究福建省高等学校重点实验室 邮 箱：caobin19@xmu.edu.cn |  |
研究领域：
胎盘是妊娠过程中发挥重要作用的临时性内分泌器官，直接介导了母体与胎儿之间的“对话”。胎盘也是目前研究最不透彻的器官之一，由其异常发育以及功能失衡导致妊娠相关疾病发病的机制尚不明确。曹彬博士近十年来一直从事胎盘发育及功能调控的分子机制以及妊娠疾病发病机理研究，作为通讯及第一作者在Cell，J Exp Med，Nucleic Acids Res，PNAS（2021，2023），Genome Res，JCI Insight，Cell Prolif，Antiviral Res及Biol Reprod等高水平学术期刊发表研究论文二十篇。曾荣获中国动物学会青年科技奖，SRI Laxmi Baxi Award及STAT Wunderkinds等多项学术奖励。实验室主要研究方向为：1）胎盘早期发育的细胞分子调控机制；2）致病微生物与宿主在母胎界面的相互作用及母胎传播机制；3）子痫前期及胎儿生长受限等重大妊娠疾病发病机理。
学习经历：
2000~2004山西大学生物科学专业 理学学士；
2005~2011中国科学院动物研究所发育生物学专业理学博士士；
工作经历：
2011~2018圣路易斯华盛顿大学 博士后；
2018~至今 皇冠hg0086客户端 教授；
重要科研项目：
1. 国家自然科学基金重点项目：胎盘维持母胎代谢互作稳态的细胞分子机制（82130047），2022-2026，主持
2. 国家重点研发计划“胎盘发育和功能调节机制” 课题三“胎盘功能障碍致子痫前期等妊娠疾病的机理”（2022YFC1004404），2022-2025
3. 国家自然科学基金面上项目：自噬基因Atg16L1再早产中的作用及机制研究（81971414），2020-2023，主持
4. 福建省自然科学基金杰出青年项目：TFEB调控胎盘屏障建立及致病微生物垂直传播的机制研究（2020J06003），2021-2023，主持
5. FIRM Grant：自噬溶酶体通路调控蜕膜胎盘功能稳态的机制研究（FIRMA200503）, 2020-2024，主持
6. 国家重点研发计划“母胎界面分子事件与病理妊娠” 课题四“胚外组织发育与子痫前期”（2018YFC1004404），2018-2021，主持
7. 国家高层次青年人才项目，2018-2023，主持
8. 皇冠“南强青年拔尖A类人才”启动经费，2018-2023，主持
获奖及荣誉：
2018 “国家高层次青年人才”
2018 福建省“闽江学者”
2018 福建省引进高层次创业创新人才
2019 厦门市“双百计划“人才
2020 福建省自然科学基金杰出青年项目获得者
2022 中国动物学会青年科技奖
2017 2017 STAT Wunderkinds Awards
2016 Laxmi Baxi Award，Society for Reproductive Investigation (SRI)
代表性成果：（*，一作；#通讯）
1. Miao Y*, Hu X*, Pan Z, Du C, Jiang J, Zheng W, Cai H, Wang Y, Deng W, Wang H, Lu J, Sun MA#, Cao B#. Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization. Nucleic Acids Research. 51:4745-59 (2023).
2. Zhou X, Xu Y, Ren S, Yang N, Sun Y, Yang Q, Yue Zhang, Han Cai, Wenbo Deng, Jingsi Chen, Dunjin Chen, Bin Cao#, Hongbo Qi#, Haibin Wang#, Jinhua Lu#. Trophoblast PR-SET7 dysfunction induces viral mimicry response and necroptosis associated with recurrent miscarriage. PNAS. 120:e2216206120(2023).
3. Du C, Jiang J, Li Y, Yu M, Jin J, Chen Shuai, Fan H, Macfarlan T, Cao B# and Sun MA#. Regulation of endogenous retrovirus–derived regulatory elements by GATA2/3 and MSX2 in human trophoblast stem cells. Genome Research. 33:197-207(2023).
4. Shao X, Cao G, Chen D, Liu J, Yu B, Liu M, Li YX, Cao B#, Sadovsky Y#, Wang YL#. Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply. PNAS. 2021 Jan 19;118(3):e2017092118.
5. Miner JJ*, Cao B* , Govero J , Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, Mysorekar IU, Diamond MS. Zika virus infection during pregnancy in mice causes placental damage and fetal demise. Cell. 165, 1081-91 (2016).
6. Cao B, Parnell LA, Diamond MS, Mysorekar I.U. Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice. J Exp Med. 7;214(8):2303-2313 (2017).
7. Cao B, Macones C, Mysorekar IU. ATG16L1 governs the placental syncytial barrier to infection and risk of premature birth in pregnant mice and women. JCI Insight. e86654 (2016).
8. Yu W, Zhang B, Hong X, Cai H, Wang Y, Lu J, Hu X#, Cao B#. Identification of desoxyrhapontigenin as a novel antiviral agent against congenital Zika virus infection. Antiviral Research. 13;211:105542 (2023).
9. Chen J, Du L, Wang F, Shao X, Wang X, Yu W, Bi S, Chen D, Pan X, Zeng S, Huang L, Liang Y, Li Y, Chen R, Xue F, Li X, Wang S, Zhuang M, Liu M, Lin L, Yan H, He F, Yu L, Jiang Q, Xiong Z, Zhang L, Cao B#, Wang YL# and Chen D#. Cellular and molecular atlas of the placenta from a COVID-19 pregnant woman infected at midgestation highlights the defective impacts on foetal health. Cell Prolif. 2022:e13204.
所有论文列表：
1. Miao Y*, Hu X*, Pan Z, Du C, Jiang J, Zheng W, Cai H, Wang Y, Deng W, Wang H, Lu J, Sun MA#, Cao B#. Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization. Nucleic Acids Research. 51:4745-59 (2023).
2. Zhou X, Xu Y, Ren S, Yang N, Sun Y, Yang Q, Yue Zhang, Han Cai, Wenbo Deng, Jingsi Chen, Dunjin Chen, Bin Cao#, Hongbo Qi#, Haibin Wang#, Jinhua Lu#. Trophoblast PR-SET7 dysfunction induces viral mimicry response and necroptosis associated with recurrent miscarriage. Proc Natl Acad Sci U S A 2023; 120:e2216206120.
3. Du C, Jiang J, Li Y, Yu M, Jin J, Chen Shuai, Fan H, Macfarlan T, Cao B# and Sun MA#. Regulation of endogenous retrovirus–derived regulatory elements by GATA2/3 and MSX2 in human trophoblast stem cells. Genome Research. 33:197-207(2023).
4. Shao X, Cao G, Chen D, Liu J, Yu B, Liu M, Li YX, Cao B#, Sadovsky Y#, Wang YL#. Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2017092118.
5. Miner JJ*, Cao B* , Govero J , Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, Mysorekar IU, Diamond MS. Zika virus infection during pregnancy in mice causes placental damage and fetal demise. Cell. 165, 1081-91 (2016). (*Co-first author).
6. Cao B, Parnell LA, Diamond MS, Mysorekar I.U. Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice. J Exp Med. 7;214(8):2303-2313 (2017).
7. Cao B, Macones C, Mysorekar IU. ATG16L1 governs the placental syncytial barrier to infection and risk of premature birth in pregnant mice and women. JCI Insight. e86654 (2016).
8. Yu W, Zhang B, Hong X, Cai H, Wang Y, Lu J, Hu X#, Cao B#. Identification of desoxyrhapontigenin as a novel antiviral agent against congenital Zika virus infection. Antiviral Research. 13;211:105542 (2023).
9. Chen J, Du L, Wang F, Shao X, Wang X, Yu W, Bi S, Chen D, Pan X, Zeng S, Huang L, Liang Y, Li Y, Chen R, Xue F, Li X, Wang S, Zhuang M, Liu M, Lin L, Yan H, He F, Yu L, Jiang Q, Xiong Z, Zhang L, Cao B#, Wang YL# and Chen D#. Cellular and molecular atlas of the placenta from a COVID-19 pregnant woman infected at midgestation highlights the defective impacts on foetal health. Cell Prolif. 2022:e13204.
10. Shao X, Yu W, Yang Y, Wang F, Yu X, Wu H, Ma Y, Cao B#, Wang YL#. The mystery of the life tree: the placentas. Biol. Reprod. 2022 Jul 25;107(1):301-316.
11. Yu W, Hu X and Cao B. Viral Infections During Pregnancy: The Big Challenge Threatening Maternal and Fetal Health. Matern Fetal Med. 2022;4:72-86.
12. Yu W, Fan L, Wang M, Cao B# and Hu X#. Pterostilbene Improves Insulin Resistance Caused by Advanced Glycation End Products (AGEs) in Hepatocytes and Mice. Mol Nutr Food Res. 2021;65:e2100321.
13. Klionsky DJ，...Cao B... Tong CK. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021;17:1-382.
14. Gilbert NM, Foster LR, Cao B, Yin Y, Mysorekar IU and Lewis AL. Gardnerella vaginalis promotes group B Streptococcus vaginal colonization, enabling ascending uteroplacental infection in pregnant mice. Am J Obstet Gynecol. 2021;224:530 e1-530 e17.
15. Bao H, Liu D, Xu Y, Sun Y, Mu C, Yu Y, Wang C, Han Q, Liu S, Cai H, Liu F, Kong S, Deng W, Cao B, Wang H, Wang Q and Lu J. Hyperactivated Wnt-beta-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2. BMC Biol. 2020;18:151.
16. Pan X, Chen J, Zhou L, Ou X, He F, Liu Y, Zheng S, Wang H, Cao B, Wang Z, Liu H, Liu G, Huang Z, Shen G, Liu S and Chen D. Efficacy and safety of continuous antiviral therapy from preconception to prevent perinatal transmission of hepatitis B virus. Sci Rep. 2020;10:13631.
17. Gorman MJ, Caine EA, Zaitsev K, Begley MC, Weger-Lucarelli J, Uccellini MB, Tripathi S, Morrison J, Yount BL, Dinnon KH, 3rd, Ruckert C, Young MC, Zhu Z, Robertson SJ, McNally KL, Ye J, Cao B, Mysorekar IU, Ebel GD, Baric RS, Best SM, Artyomov MN, Garcia-Sastre A and Diamond MS. An Immunocompetent Mouse Model of Zika Virus Infection. Cell Host Microbe. 2018;23:672-685 e6.
18. Cao B, Sheth M, Mysorekar IU. To Zika and destroy: an antimalarial drug protects fetuses from Zika infection. Future Microbiol. 2018;13:137-139.
19. Cao B*, Camden AJ*, Parnell LA, Mysorekar IU. Autophagy regulation of physiological and pathological processes in the female reproductive tract. Am J Reprod Immunol. 2017;77. (*Co-first author)
20. Cao B, Diamond MS, Mysorekar IU. Maternal-fetal transmission of Zika virus: Routes and Signals for Infection. Journal of Interferon and Cytokine Research. 37:287-294 (2017).
21. Fernandez E, Dejnirattisai W, Cao B, Scheaffer SM, Supasa P, Wongwiwat W, Esakky P, Drury A, Mongkolsapaya J, Moley KH, Mysorekar IU, Screaton GR, Diamond MS. Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection. Nature Immunology. 18(11):1261-1269 (2017).
22. Parnell LA, Briggs C, Cao B, Delannoy-Bruno O, Schrieffer AE, Mysorekar I. Microbial communities in placentas from term normal pregnancy exhibit spatially variable profiles. Scientific Reports. 11;7(1):11200 (2017).
23. Jagger BW, Miner JJ, Cao B, Arora N, Smith AM, Kovacs A, Mysorekar IU, Coyne CB, Diamond MS. Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero. Cell Host and Microbe. 13;22(3):366-376 (2017).
24. Richner MJ, Jagger RB, Shan C, Fontes CR, Dowd KA, Cao B, Himansu S, Salazar V, Caine EA, Nunes BT, Medeiros DB, Muruato AE, Foreman BM, Luo H, Wang T, Barrett AD, Weaver SC, Vasconcelos PF, Rossi SL, Ciaramella G, Mysorekar IU, Pierson TC, Shi P, Diamond MS. Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease. Cell. 170:273-283 e212 (2017).
25. Hastings AK*, Yockey LJ*, Jagger BW*, Hwang J, Uraki R, Gaitsch HF, Cao B, Mysorekar IU, Rothlin CV, Fikrig E, Diamond MS, Iwasaki A. TAM receptors are not required for Zika Virus infection in mice. Cell Reports. 19, 558-568 (2017).
26. Sapparapu G, Fernandez E, Kose N, Cao B, Fox JM, Bombardi RG, Zhao H, Nelson CA, Bryan AL, Barnes T, Davidson E, Mysorekar IU, Fremont DH, Doranz BJ, Diamond MS, and Crowe JE Jr. Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice. Nature. 540, 443-447 (2016).
27. Stout MJ, Cao B, Landeau M, French J, Macones GA, Mysorekar IU. Increased human leukocyte antigen-G expression at the maternal-fetal interface is associated with preterm birth. J Matern Fetal Neonatal Med. 28(4):454-9 (2015).
28. Cao B, Mysorekar IU. Intracellular bacteria in placental basal plate localize to extravillous trophoblasts. Placenta. 35(2):139-42 (2014).
29. Li S, Wang Y, Cao B, Wu Y, Ji L, Li YX, Liu M, Zhao Y, Qiao J, Wang H, Wang H, Han C and Wang YL. Maturation of GDF15 in human placental trophoblast cells depends on the interaction with matrix metalloproteinase-26 (MMP-26). J Clin Endocrinol Metab. 99 (11): E2277-E2287 (2014).
30. Cao B, Stout MJ, Lee I and Mysorekar IU. Placental Microbiome and Its Role in Preterm Birth. NeoReviews. 15(12):e537-e45 (2014).
31. Mysorekar IU and Cao B. Microbiome in parturition and preterm birth. Semin Reprod Med. 32(1):50-5 (2014).
32. Yang Y, Wang Y, Zeng X, Ma XJ, Zhao Y, Qiao J, Cao B, Li YX, Ji L and Wang YL. Self-control of HGF regulation on human trophoblast cell invasion via enhancing c-Met receptor shedding by ADAM10 and ADAM17. J Clin Endocrinol Metab. 97(8):E1390-401(2012).
33. Yu L, Li D, Liao QP, Yang HX, Cao B, Fu G, Ye G, Bai Y, Wang H, Cui N, Liu M, Li YX, Li J, Peng C and Wang YL. High levels of activin A detected in preeclamptic placenta induce trophoblast cell apoptosis by promoting nodal signaling. J Clin Endocrinol Metab. 97(8):E1370-9 (2012).
34. Liu J*, Cao B*, Li YX, Wu XQ and Wang YL. GnRH I and II up-regulate MMP-26 expression through the JNK pathway in human cytotrophoblasts. Reprod Biol Endocrinol. 8:5 (2010). (*Co first author)
35. Liu J, Li D, Cao B, Li YX, Herva R, Piao YS, Wang YL. Expression and localization of SWAP-70 in human fetomaternal interface and placenta during tubal pregnancy and normal placentation. J Histochem Cytochem. 55(7):701-8 (2007).
