邓文波 教授/博导 国家优青基金获得者 皇冠南强青年拔尖A类人才 学科（方向）：生殖生物学与生殖医学 所在系部：基础医学部 办公电话：0592-2880503 邮 箱：wbdeng@xmu.edu.cn |
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研究领域（200~300字介绍）：
主要关注早期妊娠过程中胚胎着床和蜕膜化、分娩启动及其异常的分子机制。妊娠是一个复杂的、受多维因素精确调控的过程，在胚胎与母体子宫的相互作用过程中仍存在很多悬而未决的谜团，如何从不同的方向和维度来厘清这一过程是我们现在所面临的挑战。妊娠成功的母体如何在正确的时间起始分娩及其背后的分子机制现在也尚不明确，由于分娩起始异常可导致早产或者难产，因此，课题组将以生物信息为主要手段，在海量的RNA-Seq、ChIP-Seq、scRNA-Seq，HiC和m6A的数据中，结合多种转基因动物模型挖掘上述生理过程中蕴含的分子调控机制。
学习经历
2001~2005 东北农业大学生命科学院 理学学士；
2005~2008 东北农业大学生命科学院 理学硕士；
2008~2013 皇冠生命科学院 理学博士；
工作经历
2013~2015 华南农业大学 博士后；
2014~2019 美国辛辛那提儿童医院医学中心 博士后、Research Associate；
2019~2022 皇冠hg0086客户端 副教授；
2022~至今 皇冠hg0086客户端 教授；
实验室网站：
http://dengwb-lab.mysxl.cn/
代表性成果：
1. Liu M‡, Deng W ‡, Tang L, Liu M, Bao H, Guo C, Zhang, Lu2 J, Wang H*, Lu Z*, Kong S*. Menin directs regionalized decidual transformation through epigenetically setting PTX3 as an obstacle balancing FGF and BMP signaling. Nat Commun, 2022
2. Lv H, Zhao G, Jiang P, Wang H, Wang Z, Yao S, Zhou Z, Wang L, Liu D, Deng W#, Dai J,# Hu Y#. Deciphering the endometrial niche of human thin endometrium at single-cell resolution. Proc Natl Acad Sci U S A. 2022
3. Du L*, Deng W*, Zeng S, Xu P, Huang L, Liang Y, Wang Y, Xu H, Tang J, Bi S, Zhang L, Li Y, Ren L, Lin L, Deng W, Liu M, Chen J, Wang H, Chen D.Single-cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion. Cell Prolif. 2021
4. Deng W*, Yuan J*, Cha JY, Sun XF, Bartos A, Yagita H, Hirota Y, Dey SK. Endothelial cells in the decidual bed are potential therapeutic targets for preterm birth prevention. Cell Reports. 2019 May
5. Jia Yuan*, Shizu Aikawa*, Wenbo Deng*, Amanda Bartos, Gerd Walz, Florian Grahammer, Tobias B Huber, Xiaofei Sun, Sudhansu K Dey. Primary Decidual Zone Formation Requires Scribble for Pregnancy Success in Mice. Nat Commun, 10(1),5425. 2019 Nov 28.
6. Shizu Aikawa*, Wenbo Deng*, Xiaohuan Liang, Jia Yuan, Amanda Bartos, Xiaofei Sun, Sudhansu K Dey, Uterine Deficiency of High-Mobility Group box-1 (HMGB1) Protein Causes Implantation Defects and Adverse Pregnancy Outcomes, Cell Death Differ, 2019 Oct 8.
7. Jeeyeon Cha, Wenbo Deng, Jia Yuan, Sudhansu K Dey. Aspects of Rodent Implantation, Encyclopedia of Reproduction. 2018 Aug 1.
8. Yuan J*, Wenbo Deng*, Cha J, Xiaofei Sun, Jean-Paul Borg, Dey SK. Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation. Nat Commun. 2018 Feb 9;9(1):603.
9. Deng WB*, Cha J*, Yuan J, Haraguchi H, Bartos A, Leishman E, Viollet B, Bradshaw HB, Hirota Y, Dey SK. p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing. J Clin Invest. 2016 Aug 1;126(8):2941-54.
10. Wei Lei, Tingting Feng, Xing Fang, You Yu, Junjie Yang, Zhen-Ao Zhao, Junwei Liu, Wenbo Deng#, Shijun Hu#. (co-corresponding author). Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes. Stem Cell Res Ther. 2018 Mar 9.
11. Deng WB, Liang XH, Liu JL, Yang ZM. Regulation and function of deiodinases during decidualization in female mice. Endocrinology. 2014. 155(7):2704-17.
12. Deng WB, Tian Z, Liang XH, Wang BC, Yang F, Yang ZM. Progesterone regulation of Na/K-ATPase β1 subunit expression in the mouse uterus during the peri-implantation period. Theriogenology. 2013. 79(8):1196-203. (F1000Prime Recommended).
主持过的重要课题：
1. 国家自然科学优秀青年基金项目， 2022/01-2024/12，200万元，主持。
2. 国家自然科学基金面上项目， 2022/01-2025/12，58万元，主持。
3. 国家自然科学基金面上项目， 2020/01-2023/12，58万元，主持。
4. 国家自然科学基金青年基金项目， 2018/01-2020/12， 20万元，主持。
5. 皇冠校长基金（成长基金）， 2019/01-2021/12，75万元，主持。
所有论文列表:
1. Liu M‡, Deng W ‡, Tang L, Liu M, Bao H, Guo C, Zhang, Lu2 J, Wang H*, Lu Z*, Kong S*. Menin directs regionalized decidual transformation through epigenetically setting PTX3 as an obstacle balancing FGF and BMP signaling. Nat Commun, 2022
2. Lv H, Zhao G, Jiang P, Wang H, Wang Z, Yao S, Zhou Z, Wang L, Liu D, Deng W#, Dai J,# Hu Y#. Deciphering the endometrial niche of human thin endometrium at single-cell resolution. Proc Natl Acad Sci U S A. 2022
3. Du L*, Deng W*, Zeng S, Xu P, Huang L, Liang Y, Wang Y, Xu H, Tang J, Bi S, Zhang L, Li Y, Ren L, Lin L, Deng W, Liu M, Chen J, Wang H, Chen D.Single-cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion. Cell Prolif. 2021
4. Zhou X, Xu Y, Ren S, Liu D, Yang N, Han Q, Kong S, Wang H, Deng W, Qi H, Lu J.Single-cell RNA-seq revealed diverse cell types in the mouse placenta at mid-gestation. Exp Cell Res. 2021
5. Zhou C, Lv M, Wang P, Guo C, Ni Z, Bao H, Tang Y, Cai H, Lu J, Deng W, Yang X, Xia G, Wang H, Wang C, Kong S. Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation. J Mol Cell Biol. 2021
6. Deng W*, Yuan J*, Cha JY, Sun XF, Bartos A, Yagita H, Hirota Y, Dey SK. Endothelial cells in the decidual bed are potential therapeutic targets for preterm birth prevention. Cell Reports. 2019 May
7. Jia Yuan*, Shizu Aikawa*, Wenbo Deng*, Amanda Bartos, Gerd Walz, Florian Grahammer, Tobias B Huber, Xiaofei Sun, Sudhansu K Dey. Primary Decidual Zone Formation Requires Scribble for Pregnancy Success in Mice. Nat Commun, 10(1),5425. 2019 Nov 28.
8. Shizu Aikawa*, Wenbo Deng*, Xiaohuan Liang, Jia Yuan, Amanda Bartos, Xiaofei Sun, Sudhansu K Dey, Uterine Deficiency of High-Mobility Group box-1 (HMGB1) Protein Causes Implantation Defects and Adverse Pregnancy Outcomes, Cell Death Differ, 2019 Oct 8.
9. Jeeyeon Cha, Wenbo Deng, Jia Yuan, Sudhansu K Dey. Aspects of Rodent Implantation, Encyclopedia of Reproduction. 2018 Aug 1.
10. Wei Lei, Tingting Feng, Xing Fang, You Yu, Junjie Yang, Zhen-Ao Zhao, Junwei Liu, Wenbo Deng#, Shijun Hu#. (co-corresponding author). Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes. Stem Cell Res Ther. 2018 Mar 9.
11. Yuan J*, Wenbo Deng*, Cha J, Xiaofei Sun, Jean-Paul Borg, Dey SK. Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation. Nat Commun. 2018 Feb 9;9(1):603.
12. Deng WB*, Cha J*, Yuan J, Haraguchi H, Bartos A, Leishman E, Viollet B, Bradshaw HB, Hirota Y, Dey SK. p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing. J Clin Invest. 2016 Aug 1;126(8):2941-54.
13. Yuan J, Cha J, Deng WB, Bartos A, Sun X, Ho HH, Borg JP, Yamaguchi TP, Yang Y, Dey SK. Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):
14. Sun X, Deng WB, Li Y, Tang S, Leishman E, Bradshaw HB, and Dey, SK. Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth. J Biol Chem. 2016a, 291, 8231-8240.
15. Sun X, Park CB, Deng WB, Potter SS, and Dey SK. Uterine inactivation of muscle segment homeobox (Msx) genes alters epithelial cell junction proteins during embryo implantation. FASEB J. 2016b. 30, 1425-1435.
16. Deng WB, Liang XH, Liu JL, Yang ZM. Regulation and function of deiodinases during decidualization in female mice. Endocrinology. 2014. 155(7):2704-17.
17. Liang XH, Deng WB, Li M, Zhao ZA, Wang TS, Feng XH, Cao YJ, Duan EK, and Yang ZM. Egr1 acts downstream of estrogen-LIF-Stat3 pathway and plays a role during implantation through targeting Wnt4. J Biol Chem. 2014. July 10 doi:10.1074/jbc.M114.588897
18. Xu X, Leng JY, Gao F, Zhao ZA, Deng WB, Liang XH, Zhang YJ, Zhang ZR, Li M, Sha AG, Yang ZM. Differential expression and anti-oxidant function of glutathione peroxidase 3 in mouse uterus during decidualization. FEBS Lett. 2014. 588(9):1580-9.
19. Huang Z, Wang TS, Zhao YC, Zuo RJ, Deng WB, Chi YJ, Yang ZM. Cyclic adenosine monophosphate-induced argininosuccinate synthase 1 expression is essential during mouse decidualization. Mol Cell Endocrinol. 2014. 388(1-2):20-31.
20. Rengaraj D, Hwang YS, Liang XH, Deng WB, Yang ZM, Han JY. Comparative expression and regulation of TMSB4X in male reproductive tissues of rats and chickens. J Exp Zool A Ecol Genet Physiol. 2013. 319(10):584-95.
21. Zhang XH, Liang X, Wang TS, Liang XH, Zuo RJ, Deng WB, Zhang ZR, Qin FN, Zhao ZA, Yang ZM. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) induction on Snail expression during mouse decidualization. Mol Cell Endocrinol. 2013. 381(1-2):272-9.
22. Zhang XH, Liang X, Liang XH, Wang TS, Qi QR, Deng WB, Sha AG, Yang ZM. The mesenchymal-epithelial transition during in vitro decidualization. Reprod Sci. 2013. 20(4):354-60.
23. Deng WB, Tian Z, Liang XH, Wang BC, Yang F, Yang ZM. Progesterone regulation of Na/K-ATPase β1 subunit expression in the mouse uterus during the peri-implantation period. Theriogenology. 2013. 79(8):1196-203. (F1000Prime Recommended).
24. Lei W, Feng XH, Deng WB, Ni H, Zhang ZR, Jia B, Yang XL, Wang TS, Liu JL, Su RW, Liang XH, Qi QR, Yang ZM. Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice. J Biol Chem. 2012 May 4;287(19):15174-92. doi: 10.1074/jbc.M111.308023.
25. Zhao ZA, Zhang ZR, Xu X, Deng WB, Li M, Leng JY, Liang XH, Yang ZM. Arachidonic acid regulation of the cytosolic phospholipase A 2α/cyclooxygenase-2 pathway in mouse endometrial stromal cells. Fertil Steril. 2012 May;97(5):1199-205.e1-9. doi: 10.1016/j.fertnstert.2012.02.011.
26. Su RW, Jia B, Ni H, Lei W, Yue SL, Feng XH, Deng WB, Liu JL, Zhao ZA, Wang TS, Yang ZM. Junctional adhesion molecule 2 mediates the interaction between hatched blastocyst and luminal epithelium: induction by progesterone and LIF. PLoS One. 2012;7(4):e34325. doi: 10.1371/journal.pone.0034325.
27. Liang XH, Zhao ZA, Deng WB, Tian Z, Lei W, Xu X, Zhang XH, Su RW, Yang ZM.Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization. Endocrinology. 2010 Oct;151(10):5007-16. doi: 10.1210/en.2010-0170.
28. Diao HL, Su RW, Tan HN, Li SJ, Lei W, Deng WB, Yang ZM. Effects of androgen on embryo implantation in the mouse delayed-implantation model. Fertil Steril. 2008 Oct;90(4 Suppl):1376-83.
29. Rengaraj D, Liang XH, Gao F, Deng WB, Mills N, Yang ZM. Differential expression and regulation of integral membrane protein 2b in rat male reproductive tissues. Asian J Androl. 2008 May;10(3):503-11.
30. Sun T, Deng WB, Diao HL, Ni H, Bai YY, Ma XH, Xu LB, Yang ZM. Differential expression and regulation of prostaglandin E synthases in the mouse ovary during sexual maturation and luteal development. J Endocrinol. 2006 Apr;189(1):89-101.
