个人简介

张凌娟博士在美国有近15年分子生物学和基础医学领域的学习研究经历，及近10年皮肤医学专项领域的研究经验。特别是近年在皮肤天然免疫机制及调控领域开展了一系列独创性的研究工作，发现脂肪前体细胞 (Preadipocytes/Adipocytes) 有免疫抑菌功能,可通过大量释放多肽抗生素来抵御细菌感染，这种抗菌多肽还在表皮角化细胞 (Keratinocytes) 里参与银屑病皮肤炎症的调控, 上述研究成果以第一作者身份在Science、Immunity 和Current Biology等国际顶级学术期刊上，多次受邀在国际学术会议上做学术报告。2011年起，为Journal of Investigative Dermatology、Journal of Biological Chemistry、Oncotarget等杂志担任专业审稿人审阅了近100篇研究论文。 2007年至2011年，担任American Association of Cancer Research (AACR) 专业协会成员； 2011起担任Society of Investigative Dermatology (SID) 专业协会成员。 在UCSD期间以PI身份主持美国国立卫生研究院(NIH) R01研究课题。 2018年加入皇冠药学院，将继续紧密围绕皮肤宿主细胞免疫调控分子机制开展基础研究。同时将利用厦大药学院在转化医学创新药物研发方面的成熟经验，充分挖掘药物库储备和药物化学的传统优势，在药学院组建以皮肤病免疫调控为靶点策略的全新药物研发平台，利用原代细胞库、3D皮肤模型等前沿手段，与厦大附属医院相关科室开展的临床转化研究合作，促进科研成果应用于临床。

学习经历

2009  博士  美国俄勒冈州立大学，专业：药理学

2003  学士  北京理工大学，专业：生物工程

工作经历

2018-至今  教授，皇冠药学院

2014-2018  项目科学家，美国加州大学圣地亚哥分校，皮肤医学系，皇冠

2011-2014  博士后，美国加州大学圣地亚哥分校，皮肤医学系，皇冠

2009-2011  博士后，美国俄勒冈州立大学，药学院

代表性成果

1.Ling-juan Zhang. Keratin ("Biochemistry" Book Series). In press, 2018. ISBN 978-953-51-6296-4. Book chapter title: Keratins in Skin Epidermal Development and Diseases.

2.Toshiya Takahashi, Nikhil Nitin Kulkarni, Ernest Y Lee, Ling-juan Zhang, Gerard C.L. Wong, Richard L. Gallo. Scientific Report, 2018, 8, Article number: 4032 (2018). Title: Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors.

3.Nikhil N Kulkarni, Christopher A Adase, Ling-juan Zhang, Andrew W Borkowski, Fengwu Li, James A Sanford, Daniel J Coleman, Carlos Aguilera, Arup K Indra, Richard L Gallo. Journal of Investigative Dermatology, Volume 137, Issue 11, November 2017, Pages 2417-2426. Title:Interleukin-1 receptor knockout mice develop epidermal cysts and show an altered innate immune response following exposure to ultraviolet B radiation

4.Fengwu Li, Chris Adase and Ling-juan Zhang (contact author). Journal of Visualized Experiments, e5602, 2017. Title: Isolation and culture of primary mouse keratinocytes from neonatal and adult mouse skin.

5.Emi Sato, Lingjuan Zhang, Robert Dorschner, Chris Adase, Biswa Choudhury, and Richard Gallo. Journal of Investigative Dermatology, 2017 Apr 25. pii: S0022-202X(17)31424-0.,2017. Title:Activation of parathyroid hormone 2 receptor induces decorin expression and promotes wound repair

6.Yanhan Wang, Ling-juan Zhang, Jinghua Yu, Stephen Huang, Zhenping Wang, Kimberly Ann Chun, Tammy Ling Lee, Richard L. Gallo and Chun-Ming Huang. Journal of Investigative Dermatology, 2017 Jan;137(1):46-56. Title:A Co-drug of Butyric Acid Derived from Fermentation Metabolites of the Human Skin Microbiome Stimulates Adipogenic Differentiation of Adipose-Derived Stem Cells: Implications in Tissue Augmentation

7.James A. Sanford, Ling-juan Zhang, Michael R. Williams, Jon A. Gangoiti, Chun-Ming Huang and Richard L. Gallo. Science Immunology, 28 Oct 2016: Vol. 1, Issue 4, eaah4609. Title: Inhibition of HDAC8 and HDAC9 by microbial short-chain fatty acids breaks immune tolerance of the epidermis to TLR ligands.

8.Ling-juan Zhang, George L. Sen, Nicole L. Ward, Andrew Johnston, Kimberly Chun, Yifang Chen, Christopher Adase, James A. Sanford, Nina Gao, Melanie Chensee, Emi Sato, Yi Fritz, Jaymie Baliwag, Michael R. Williams, Tissa Hata, Richard L. Gallo. Immunity, 2016 Jul 19;45(1):119-30. Title: Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injury.

9.Christopher A. Adase, Andrew Borkowski, Ling-juan Zhang, Michael Williams, James A Sanford and Richard L. Gallo. (2016)Journal of Biological Chemistry, 2016 May 27;291(22):11635-46. Title: Non-coding double-stranded RNA and LL-37 induce growth factor expression from keratinocytes and endothelial cells

10.Emi Sato, Jun Muto, Ling-juan Zhang, Chris Adase, James A. Sanford, Toshi Takahashi, Teru Nakatsuji, Robert A. Lee, and Richard L Gallo (2016). Journal of Investigative Dermatology, 74(4):772-4,Title: The parathyroid hormone second receptor PTH2R, and its ligand tuberoinfundibular peptide of 39 residues TIP39, regulate intracellular calcium and influence keratinocyte differentiation.

11.Ling-juan Zhang and Richard Gallo, (2016)Current Biology, Jan 11;26(1):R14-9. Title: Antimicrobial peptides (Review article).

12.Bouslimani A, Porto C, Rath CM, Berg-Lyon D, Ackermann G, Nakatsuji T, Zhang LJ, Borkowski AW, Meehan MJ, Dorrestein K, Gallo RL, Bandeira N, Knight R, Alexandrov T, Dorrestein PC. (2015) Proc Natl Acad Sci U S A, Apr 28;112(17):E2120-9.,Title:Molecular cartography of the human skin surface in 3D.

13.Ling-juan Zhang, Christian F. Guerrero-Juarez, Tissa Hata, Sagar P. Bapat, Raul Ramos, Maksim V. Plikus, Richard L. Gallo. (2015) Science, 347(6217):67-71, Title:Dermal adipocytes protect against invasive Staphylococcus aureus skin infection

14.Ling-juan Zhang, Zhixing Wang (co-first author), Gunjan Guha, Shan Li, Kateryna Kyrylkova, Chrissa Kioussi, Mark Leid, Gitali Ganguli-Indra, Arup K. Indra. (2012) Plos One, 7(12): e51262. Title: Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-like Skin Inflammatory Responses in Adult Mice

15.Zhang LJ, Bhattacharya S, Leid M, Ganguli-Indra G, Indra AK. (2012)Journal of Cell Science, 125, 5733-5744;Title: Ctip2 is a dynamic regulator of epidermal proliferation and differentiation by integrating EGFR and Notch signaling.

16.Zhang LJ, Vogel WK, Liu X, Topark-Ngarm A, Arbogast BL, Maier CS, Filtz TM, Leid M. (2012) Journal of Biological Chemistry, 287(32):26971-88; Title: Coordinated regulation of transcription factor Bcl11b activity in thymocytes by the mitogen-activated protein kinase (MAPK) pathways and protein sumoylation.

17.Zhang, L. J., Liu, X., Gafken, P. R., Kioussi, C., and Leid, M. (2009) Journal of Biological Chemistry, 284, 6156-6168; Title: A Chicken Ovalbumin Upstream Promoter Transcription Factor I (COUP-TFI) Complex Represses Expression of the Gene Encoding Tumor Necrosis Factor a-induced Protein 8 (TNFAIP8); Note: This is paper was selected by JBC as the paper of the week, which is about top 1% of all 6600 papers published each year in JBC.

18.Kastner P, Chan S, Vogel WK, Zhang LJ, Topark-Ngarm A, Golonzhka O, Jost B, Le Gras S, Gross MK, Leid M.(2010) Eur J Immunol., Title: Bcl11b represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytes