个人简介

担任中国化学会化学生物学专业委员会副主任、谱学分析与仪器教育部重点实验室副主任；ACS Applied Bio Materials 副主编;  BMC Biochemistry 副主编、Analytical Chemistry、Lab on a Chip、Analyst、Talanta、Biomicrofluidics、Scientific Reports、Analytical and Bioanalytical Chemisry、Journal of Analysis and Testing、《分析化学》 、《分析测试学报》等期刊编委/顾问编委。
近年主持主要科研项目包括：国家重大科研仪器研制项目、科技部国家重点研发计划合成生物学专项课题、国家自然科学基金委重点项目、国家杰出青年科学基金、科技部973课题、科技部国家重大科学仪器设备开发专项子任务、国家自然科学基金委面上项目等。　　
先后获得美国化学会分析化学研究生奖、中国政府优秀自费留学生奖、中美化学与化学生物学教授协会杰出教授奖、福建省五四青年奖章、福建省运盛青年科技奖、福建省杰出青年基金、国家杰出青年科学基金、福建省高校领军人才、福建省科技创新领军人才、厦门市双百计划领军型创业人才、福建省自然科学优秀学术论文一等奖、中国青年分析化学家奖、中国化学会-英国皇家化学会青年化学奖、科技部中青年科技创新领军人才、中组部等9部委《全民科学素质行动计划纲要》实施工作先进个人、福建省科技进步一等奖、美国化学会测量科学进展讲座奖等奖项与称号。

研究领域

1.体外诊断新技术

2.细胞识别、富集与成像

3.高通量单细胞测序

4.微流控技术在生物医学中的应用

5.生物医学仪器

学习经历

2006年 美国佛罗里达大学  博士

2001年 皇冠  硕士

1998年 皇冠  学士

工作经历

2007~至今 皇冠化学化工学院

2006~2007 美国加州大学伯克利分校  博士后

近期主要代表论著

1. Sun, M; Liu, S; Wei, X; Wan, S; Huang, M; Song, T; Lu, Y; Weng, X; Zhu, L; Chen, H*; Song, Y*; Yang, C*; Aptamer Blocking Strategy Inhibits SARSCoV2 Virus Infection, Angew. Chem. Int. Ed. 2021, 60, DOI: 10.1002/anie.202100225

2. Lin, L; Du, Y; Song, J; Wang, W*; Yang,C*; Imaging Commensal Microbiota and Pathogenic Bacteria in the Gut, Acc. Chem. Res. 2021, 10.1021/acs.accounts.1c00068

3. Lin, B; Tian, T; Lu, Y; Liu, D; Huang, M; Zhu, L; Zhu, Z; Song, Y*; Yang, C*; Tracing Tumor-derived Exosomal PD-L1 by Dual-aptamer Activated Proximity-induced Droplet Digital PCR, Angew. Chem. Int. Ed. 2021, 60, 7582-7586.

4. Wu, L; Wang, Y; Xu,X; Liu, Y; Lin, B; Zhang, M, Zhang, J; Wan, S; Yang, C*; Tan, W*; Aptamer-Based Detection of Circulating Targets for Precision Medicine, Chem. Rev. 2021, DOI: 10.1021/acs.chemrev.0c01140.

5. Huang, M^#; Li,T^#; Xu, Y; Wei, X; Song, J; Lin,B; Zhu, Z; Song, Y*; and Yang, C*; Activation of Aptamers with Gain-of-Function by Small-Molecule Clipping of Intramolecular Motifs, Angew. Chem. Int. Ed. 2021, 6021-6028

6. Ruan, Q; Ruan, W; Lin, X; Wng, Y; Zou, F; Zhou, L; Zhu, Z, Yang, C*; Digital-WGS: automated, highly efficient whole-genome sequencing of single cells by digital microfluidics, Sci. Adv., 2020, 6, eabd6454

7. Lin, L; Wu, Q; Song, J; Du, Y; Gao, J; Song, Y; Wang, W*; Yang, C*; Revealing the in vivo growth and division patterns of mouse gut bacteria, Sci. Adv., 2020, 6: eabb2531.

8. Zhang, M; Zou, Y; Xu, X; Zhang, X; Gao, M; Song, J; Huang, P; Chen, Q; Zhu, Z; Lin, W; Zare, R; Yang, C*; Highly Parallel and Efficient Single Cell mRNA Sequencing with Paired Picoliter Chambers. Nat. Commun., 2020, 11, 2118.

9. Wang, W*; Zhang, N; Du, Y; Gao, J; Li, M; Lin, L; Czajkowsky, D; Li, X*; Yang, C*; Shao, Z; Three-dimensional Quantitative Imaging of Native Microbiota Distribution in the Gut. Angew. Chem. Int. Ed., 2020, DOI: 10.1002/anie.202010921.

10. Zhang, J; Lin, B; Wu, L; Huang, M; Li, X; Zhang, H; Song, J; Wang, W; Zhao, G*; Song, Y*; Yang, C*; DNA Nanolithography Enables Highly Ordered Recognition Interface in Microfluidic Chip for Efficient Capture and Release of Circulating Tumor Cells, Angew. Chem. Int. Ed., 2020, 59, 14115-14119

11. Lin, L; Song, J; Du, Y; Wu, Q; Gao, J; Song, Y; Yang, C*; Wang, W*; Quantification of Bacterial Metabolic Activities in the Gut by D-Amino Acid-based in vivo Labeling. Angew. Chem. Int. Ed., 2020, 59, 11923-11926.

12. Wu, L; Ding, H; Qu, X; Shi, X; Yang, J; Huang, M; Zhang, J; Zhang, H; Song, J; Zhu, L; Song, Y*; Ma, Y*; Yang, C*; Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability. J. Am. Chem. Soc., 2020, 142, 4800-4806

13. Huang, M; Yang, J; Wang, T; Song, J; Xia, J; Wu, L; Wang, W; Wu, Q; Zhu, Z; Song, Y*; Yang, C*; Homogeneous, Low-volume, Efficient and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction. Angew. Chem. Int. Ed., 2020, 59, 4800-4805.

14. Wang, W; Yang, Q; Du, Y, Zhou, X, Du, X, Wu, Q, Lin, L, Song, Y, Li, F, Yang, C*, Tan, W*. Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables in vivo Imaging of Gut Microbiota. Angew. Chem. Int. Ed., 2020,59, 2628-2633

15. Wang, W; Lin, L; Du, Y; Song, Y; Peng, X; Chen, X*; Yang, C*; Assessing the Viability of Transplanted Gut Microbiota by Sequential Tagging with D-Amino acid-based Metabolic Probes. Nature Commun., 2019, 10, 1317

16. Li, Y; Ma, Y; Jiao, X; Li, T; Lv, Z; Yang, C*; Zhang, X*; Wen, Y*; Control of capillary behavior through target-responsive hydrogel permeability alteration for sensitive visual quantitative detection. Nature Commun., 2019, 10, 1036

17. Song, Y; Shi, Y; Huang, M; Wang, W; Wang, Y; Cheng, J; Lei, Z; Zhu, Z; Yang, C*; Bioinspired Engineering of Multivalent Aptamer-Functionalized Nanointerface to Enhance Capture and Release of Circulating Tumor Cells. Angew. Chem. Int. Ed., 2019, 58, 2236-2240

18. Chen, Y; Ke, G*; Ma, Y; Zhu, Z; Liu, M; Liu, Y; Yan, H*; Yang, C*; A Synthetic Light-Driven Substrate Channeling System for Precise Regulation of Enzyme Cascade Activity Based on DNA Origami. J. Am. Chem. Soc.,2018,  28, 8990-8996

19. Gashaw, M; Abate, M; Song, Y; Zhu, Z; Yan, F; Xu, Y; Wang, X; Li, Q; Yang, C*; Isolation, Detection and Antigen Based Profiling of Circulating Tumor Cells Using a Size Dictated Immunocapture Chip. Angew. Chem. Int. Ed., 2017, 56, 10681-10685

20. Zhu, Z; Yang, C*; Hydrogel Droplet Microfluidics for High-Throughput Single Molecule/Cell Analysis. Acc. Chem. Res. 2017, 50, 22-31

21. Ke, G; Liu, M; Jiang, S; Qi, X; Yang, Y, Wootten S; Zhang, F; Zhu, Z; Liu, Y*; Yang, C*; Yan H*; Directional Regulation of Enzyme Pathways via the Control of Substrate Channeling on a DNA Origami Scaffold.  Angew. Chem. Int. Ed., 2016, 55, 7483-7486

22. Zhu, Z; Guan,Z; Liu, D; Jia, S; Li, J; Lei, Z; Lin, S; Ji, T; Tian, Z; Yang, C*; Translating Molecular Recognition into Pressure Signal for Rapid, Sensitive, and Portable Biomedical Analysis. Angew. Chem. Int. Ed., 2015, 54,10448-10453

23. Zhu Z; Guan, Z; Jia S;Lei Z; Lin, S; Zhang, H; Ma, Y; Tian, Z; Yang, C*; Au@Pt Nanoparticle Encapsulated Target-responsive Hydrogel with Volumetric Bar-chart Chip Readout for Quantitative Point-of-care Testing. Angew. Chem. Int. Ed., 2014, 53, 12503-12507

24. Tan, J; Ding L; Ju H*; Yang Y; Li X; Shen Z; Zhu Z; Yu J*; Yang C*; A Multifunctional Nanomicelle for Real-Time Targeted Imaging and Precise Near-Infrared Therapy of Cancer. Angew. Chem. Int. Ed., 2014, 53, 9544-9549

25. Xiong, X; Liu, H; Zhao, Z; Altman, M; Lopez-Colon, D; Yang, C*, Chang, L; Liu, C; Tan, W*. DNA Aptamer-mediated Cell Targeting. Angew. Chem. Int. Ed., 2013, 53, 1472-1476

26. Yan, L; Zhu, Z; Zou, Y; Huang, Y; Liu, D; Jia, S; Xu, D; Wu, M;Zhou, Y; Zhou, S; Yang, C*; Target-responsive “Sweet” Hydrogel with Glucometer Readout: an Effective Method for Portable and Quantitative Detection of Non-glucose Targets. J. Am. Chem. Soc., 2013, 135,3748–3751

27. Ke, G; Wang, C; Ge Y; Zheng, N; Zhu Z; Yang, C*; L-DNA Molecular Beacons: A Safe, Stable, and Accurate Intracellular Nano-thermometer for Temperature Sensing in Living Cells. J. Am. Chem. Soc., 2012, 134,18908-18911

28. Huang, J; Wu, Y; Chen, Y; Zhu, Z; Yang, X; Yang, C*; Wang, K*; Tan, W*. Pyrene Excimer Probes for Nucleic Acids in Complex Biological Fluids Based on Hybridization Chain Reaction Amplification. Angew. Chem. Int. Ed., 2011, 50, 401-404

29. Zhu, Z; Wu, C; Liu, H; Zou, Y; Zhang, X; Kang, H; Yang, C*; Tan, W*. Aptamer-Crosslinked Hydrogel as a Colorimetric Platform for Visual Detection. Angew. Chem. Int. Ed., 2010, 49, 1052-1056

30. Yang, C; Martinez, K; Lin, H; Tan, W; Hybrid molecular probe for nucleic acid analysis in biological samples. J. Am. Chem. Soc. 2006, 128, 9986-9987.

31. Yang, C; Jockusch, S.; Vicens, M.; Turro, N J; Tan, W; Light-switching excimer probes for rapid protein monitoring in complex biological fluids. Proc. Natl. Acad. Sci. U. S. A 2005, 102 , 17278-17283.

32. Yang, C; Lin, H; Tan, W; Molecular assembly of superquenchers in signaling molecular interactions. J. Am. Chem. Soc. 2005, 127 , 12772-12773.

33. Yang, C; Pinto, M; Schanze, K; Tan, W; Direct synthesis of an oligonucleotide-poly(phenylene ethynylene) conjugate with a precise one-to-one molecular ratio. Angew. Chem. Int. Ed. 2005, 44 , 2572-2576.