研究领域

营养感应关键蛋白质和信号通路在生理和病理状态下的调控方式和作用机制，具体包括AIDA、AXIN1和p53等代谢调控枢纽蛋白以及GSK3-TIP60-ULK营养感应信号通路在营养感应、糖脂代谢以及肥胖、糖尿病和肿瘤等代谢性疾病发生发展过程中的调控和功能实现机制。

学习经历

2006~2009 皇冠生命科学学院  博士；

2003~2006 香港科技大学生物化学系  博士；

1999~2003 皇冠生命科学学院  学士。

工作经历

2018~至今 皇冠生命科学学院  教授；

2012~2018 皇冠生命科学学院  副教授；

2009~2012 皇冠生命科学学院  助理教授。

代表性成果

1. Lin SY, Zhang CS, Lin SC(*). Carbohydrates: Not All that Bad? Cell Metabolism 2018 28: 671-672. 

2. Li TY(#), Song L(#), Sun Y(#), Li J, Yi C, Lam SM, Xu D, Zhou L, Li X, Yang Y, Zhang CS, Xie C, Huang X, Shui G, Lin SY, Reue K, Lin SC(*). Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nature Communication 2018 9: 1916. 
3. Luo H(#), Jiang M(#), Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY(*), Lin SC(*). AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity. Cell Metabolism 2018 27: 843-853. 
4. Sun Y(#), Li TY(#), Song L(#), Zhang C, Li J, Lin ZZ, Lin SC, Lin SY(*). Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury. Hepatology 2018 67: 2397-2413. 
5. Li TY, Sun Y, Liang Y, Liu Q, Shi Y, Zhang CS, Zhang C, Song L, Zhang P, Zhang X, Li X, Chen T, Huang HY, He X, Wang Y, Wu YQ, Chen S, Jiang M, Chen C, Xie C, Yang JY, Lin Y, Zhao S, Ye Z, Lin SY, Chiu DT, Lin SC(*). ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy. Molecular Cell 2016 62: 359-370. 
6. Zheng LS(#), Liu YT(#), Chen L, Wang Y, Rui YN, Huang HZ, Lin SY, Wang J, Wang ZX, Lin SC, Wu JW(*). Structure and mechanism of the unique C2 domain of Aida. FEBS J. 2014 281: 4622-4632. 
7. Li TY, Lin SY, Lin SC(*). Mechanism and physiological significance of growth factor-related autophagy. Physiology (Bethesda) 2013 28: 423-431. 
8. Ruan K(#), Ye F(#), Li C(#), Liou YC, Lin SC, Lin SY(*). PLK1 Interacts and Phosphorylates Axin That Is Essential for Proper Centrosome Formation. PLoS One 2012 7: e49184. 
9. Lin SY(#), Li TY(#), Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC(*). Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy. Autophagy 2012 8: 1385-1386. 
10. Lin SY(#), Li TY(#), Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC(*). GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy. Science 2012 336: 477-481. 
11. Li Q(#), Lin S(#), Wang X(#), Lian G, Lu Z, Guo H, Ruan K, Wang Y, Ye Z, Han J, Lin SC(*). Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nature Cell Biology 2009 11: 1128-1134. 
12. Lin S(#), Wang J, Ye Z, Ip NY, Lin SC(*). CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5. FEBS Letters 2008 582: 1197-1202. 
13. Rui Y(#), Xu Z(#), Xiong B(#), Cao Y(#), Lin S, Zhang M, Chan SC, Luo W, Han Y, Lu Z, Ye Z, Zhou HM, Han J, Meng A(*), Lin SC(*). A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Developmental Cell 2007 13: 268-282. 
14. Rui Y(#), Xu Z(#), Lin S, Li Q, Rui H, Luo W, Zhou HM, Cheung PY, Wu Z, Ye Z, Li P, Han J, Lin SC(*). Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO Journal 2004 23: 4583-4594.

获奖及荣誉

1. 福建省特殊支持人才“双百计划”青年拔尖创新人才，2016年；

2. 国家优秀青年科学基金获得者，2018年