楚成超 副教授 学科（方向）：眼科学 所在系部：眼科研究所 办公电话：0592-2183761 邮 箱：chuchengchao@xmu.edu.cn 系部网址：https://eye.xmu.edu.cn |
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研究领域：
多年来致力于药物超分子组装的设计、制备及性能评价等工作，尤其在血管新生相关疾病模型上的应用研究方面具备了丰富的理论及实践基础，并且系统探索验证新生血管靶向治疗新策略。通过研究生物安全性较高的金属离子和临床用药物之间的配位组装机制，进而可控实现药物高效超分子组装。提出并科学阐述了一种新型的超分子药物组装理论方法。
基于此的研究方向有：眼部共组装制剂、眼药水的研发；眼部新生血管相关疾病诊疗一体化的研究；眼部经血管介入治疗。
学习经历：
2014~2018 皇冠公共卫生学院生物化学与分子生物学专业 理学博士
2012~2014 济南大学化学化工学院分析化学专业 理学硕士
2007~2011 济南大学化学化工学院应用化学专业 理学学士
工作经历：
2018~2021 皇冠公共卫生学院 博士后
2021.04~2021.11 皇冠hg0086客户端 助理教授
2021.11~至 今 皇冠hg0086客户端 副教授
社会及学术兼职：
中国生物医学工程学会会员；中国材料学会会员。
代表性成果：
1. Dong Li, Yang Yang, Dengfeng Li, Jie Pan, Chengchao Chu*, Gang Liu*. Organic Sonosensitizers for Sonodynamic Therapy: From Small Molecules and Nanoparticles toward Clinical Development, Small, 2021, 202101976.
2. Dongsheng Li#, Qixuan Dai#, Hu Chen#, Huirong Lin, Zhixiang Lu, Huili Zheng, Peng Lv, Wei Li*, Gang Liu*, Chengchao Chu*. Metal-organic Nanostructure Based on TixOy/Ruthenium Reaction Units: For CT/MR Imaging-Guided X-ray Induced Dynamic Therapy, Chemical Engineering Journal, 2021, 202000416.
3. Huili Zheng,# Baoxin Ma,# Yesi Shi, # Qixuan Dai, Dongsheng Li, En Ren, Jing Zhu, Jianming Liu, Hu Chen, Zhenyu Yin, Chengchao Chu,* Xiaomin Wang,* Gang Liu.* Tumor Microenvironment-Triggered MoS2@GA-Fe Nanoreactor: A Self-Rolling Enhanced Chemodynamic Therapy and Hydrogen Sulfide Treatment for Hepatocellular Carcinoma. Chemical Engineering Journal, 2021, 406, 126888.
4. Xiaoxiao Shi,# Yang Zhang,# Ye Tian,# Shuyu Xu, En Ren, Shuang Bai, Xiaoyuan Chen, Chengchao Chu,* Zhigang Xu,* and Gang Liu*. Multi-responsive Bottlebrush-Like Unimolecules Self-Assembled Nano-Riceball for Synergistic Sono-Chemotherapy. Small Methods, 2021, 202000416.
5. Chengchao Chu, *# Jingwen Yu,# En Ren,# Shangkun Ou, Yunming Zhang, Yiming Wu, Han Wu, Yang Zhang, Jing Zhu, Qixuan Dai, Xiaoyong Wang, Qingliang Zhao, Wei Li,* Zuguo Liu, Xiaoyuan Chen, and Gang Liu*. Multimodal Photoacoustic Imaging-Guided Regression of Corneal Neovascularization: A Non-invasive and Safe Strategy. Advanced Science, 2020, 202000346.
6. Min Su,# Qixuan Dai,# Chuan Chen, Yun Zeng, Chengchao Chu,* Gang Liu.* Nano-Medicine for Thrombosis: A Precise Diagnosis and Treatment Strategy. Nano-micro letters, 2020, 12:96
7. Hu Chen,# Hongwei Cheng,# Qixuan Dai,# Yi Cheng,# Yang Zhang, Dengfeng Li, Yang Sun, Jingsong Mao,* Ke Ren, Chengchao Chu,* Gang Liu.* A superstable homogeneous lipiodolICG formulation for locoregional hepatocellular carcinoma treatment. Journal of Controlled Release, 2020, 323, 635-643
8. Chengchao Chu#, Min Su#, Jing Zhu#, Dongsheng Li, Hongwei Cheng, Junqing Wang, Xiaoyuan Chen and Gang Liu*. Metal-Organic Framework Nanoparticle-Based Biomineralization: A New Strategy toward Cancer Treatment. Theranostics, 2019; 9(11): 3134-3149.
9. Chengchao Chu,# En Ren,# Yunming Zhang, Jingwen Yu, Huirong Lin, Xin Pang, Yang Zhang, Heng Liu, Zainen Qin, Yi Cheng, Xiaoyong Wang, Wei Li, Xiangjian Kong, Xiaoyuan Chen and Gang Liu.* Zinc (II)‐Dipicolylamine Coordination Nanotheranostics: Toward Synergistic Nanomedicine by Combined Photo/Gene Therapy. Angewandte Chemie International Edition, 2019, 58(1): 269 –272. (ESI Highly Cited Paper)
10.Chengchao Chu,# Huirong Lin,# Heng Liu, Xiaoyong Wang, Junqing Wang, Pengfei Zhang, Haiyan Gao, Chao Huang, Yun Zeng, Yuanzhi Tan, Gang Liu,* and Xiaoyuan Chen. Tumor Microenvironment‐Triggered Supramolecular System as an In Situ Nanotheranostic Generator for Cancer Phototherapy, Advanced Materials, 2017, 1605928. (Cover picture)
主持过的重要课题：
1. 国家自然科学基金青年科学基金项目，可降解自组装纳米载药体系在角膜血管新生协同诊疗中的应用研究，2020.1-2022.12
2. 中国博士后基金面上项目，基于光学/基因协同的角膜新生血管治疗研究，2019.6-2020.9
3. 广东省自然科学基金面上项目，多功能自发射光动力栓塞微球在肝癌治疗中的应用，2021.1-2023.12
已申请的专利：
1. 刘刚，朱靖，楚成超，李东升，石业思，张阳，任恩，一种具有声动力治疗效果的金属-卟啉纳米颗粒、制备方法及其应用，2020.08.18，ZL201811390306.7
2. 刘刚，林惠荣，楚成超，李霜，庞鑫，一种脂质体微泡载金属-ICG自组装复合体系，2020.10.02，ZL201810461899.5
3. 刘刚，楚成超，林惠荣，张阳，高海燕，葛胜祥，一种无酶病原体比色分析检测传感器，2016.7.22，中国，ZL201610581667.4
所有论文列表：
1. Dong Li, Yang Yang, Dengfeng Li, Jie Pan, Chengchao Chu*, Gang Liu*. Organic Sonosensitizers for Sonodynamic Therapy: From Small Molecules and Nanoparticles toward Clinical Development, Small, 2021, 20210197.
2. Dongsheng Li#, Qixuan Dai#, Hu Chen#, Huirong Lin, Zhixiang Lu, Huili Zheng, Peng Lv, Wei Li*, Gang Liu*, Chengchao Chu*. Metal-organic Nanostructure Based on TixOy/Ruthenium Reaction Units: For CT/MR Imaging-Guided X-ray Induced Dynamic Therapy, Chemical Engineering Journal, 2021, 202000416.
3. Huili Zheng,# Baoxin Ma,# Yesi Shi, # Qixuan Dai, Dongsheng Li, En Ren, Jing Zhu, Jianming Liu, Hu Chen, Zhenyu Yin, Chengchao Chu,* Xiaomin Wang,* Gang Liu.*Tumor Microenvironment-Triggered MoS2@GA-Fe Nanoreactor: A Self-Rolling Enhanced Chemodynamic Therapy and Hydrogen Sulfide Treatment for Hepatocellular Carcinoma.Chemical Engineering Journal, 2021, 406, 126888.
4. Xiaoxiao Shi,# Yang Zhang,# Ye Tian,# Shuyu Xu, En Ren, Shuang Bai, Xiaoyuan Chen, Chengchao Chu,* Zhigang Xu,* and Gang Liu*. Multi-responsive Bottlebrush-Like Unimolecules Self-Assembled Nano-Riceball for Synergistic Sono-Chemotherapy.Small Methods, 2021, 202000416.
5. Jingwen Yu, # Chengchao Chu, # Yiming Wu, Gang Liu, Wei Li.The phototherapy toward corneal neovascularization elimination: An efficient, selective and safe strategy. Chinese Chemical Letters, 2021, 32, 199-101.
6. Chengchao Chu, *# Jingwen Yu,# En Ren,# Shangkun Ou, Yunming Zhang, Yiming Wu, Han Wu, Yang Zhang, Jing Zhu, Qixuan Dai, Xiaoyong Wang, Qingliang Zhao, Wei Li,* Zuguo Liu, Xiaoyuan Chen, and Gang Liu*. Multimodal Photoacoustic Imaging-Guided Regression of Corneal Neovascularization: A Non-invasive and Safe Strategy. Advanced Science, 2020, 202000346.
7. Min Su,# Qixuan Dai,# Chuan Chen, Yun Zeng, Chengchao Chu,* Gang Liu.* Nano-Medicine for Thrombosis: A Precise Diagnosis and Treatment Strategy. Nano-micro letters,2020, 12:96.
8. Hu Chen,# Hongwei Cheng,# Qixuan Dai,# Yi Cheng,# Yang Zhang, Dengfeng Li, Yang Sun, Jingsong Mao,* Ke Ren, Chengchao Chu,* Gang Liu.* A superstable homogeneous lipiodolICG formulation for locoregional hepatocellular carcinoma treatment. Journal of Controlled Release, 2020, 323, 635-643.
9. En Ren, # Chengchao Chu, # Yunming Zhang#, Junqing Wang, Xin Pang, Xiaoning Lin, ChaoLiu, Xiaoxiao Shi, Qixuan Dai, Peng Lv, Xiaomin Wang, Xiaoyuan Chen, Gang Liu*. MimovirusVesicle-based Biological Orthogonal Reaction for Cancer Diagnosis. Small Methods, 2020, 202000291.
10. Dazhuang Xu, Lei Li, Chengchao Chu,* Xiaoyong Zhang,* Gang Liu.* Advances and perspectives in near-infrared fluorescent organic probes for surgical oncology. WIREs Nanomedicine & Nanobiotechnology, 2020, 12(5):e1635.
11. Haiyan Gao, # Chengchao Chu,# Yi Cheng, Yang Zhang, Xin Pang, Dengfeng Li, Xiaoyong， Wang, En Ren, Fengfei Xie, Yan Bai, Lijuan Chen, Gang Liu*, Meiyun Wang*.ACS Applied Materials & Interfaces, 2020, 12, 26880-26892
12. Hu Chen,# Hongwei Cheng,# Wenying Wu,# Dengfeng Lia, Jingsong Mao,* Chengchao Chu,* Gang Liu.* The Blooming Intersection of Transcatheter Hepatic Artery Chemoembolization and Nanomedicine. Chinese Chemical Letters, 2020, 31, 1375-1381
13. Chuan Chen, Rui Tian, Yun Zeng, Chengchao Chu*, Gang Liu*. Activatable fluorescence probes for “turn-on” and ratiometric biosensing and bioimaging: from NIR-I to NIR-II. Bioconjugate Chemistry, 2020, 31, 2, 276-292.
14. Chengchao Chu,# Huirong Lin,# Heng Liu, Xiaoyong Wang, Junqing Wang, Pengfei Zhang, Haiyan Gao, Chao Huang, Yun Zeng, Yuanzhi Tan, Gang Liu,* and Xiaoyuan Chen. Tumor Microenvironment‐Triggered Supramolecular System as an In Situ Nanotheranostic Generator for Cancer Phototherapy, Advanced Materials, 2017, 1605928.
15. Chengchao Chu,# En Ren,# Yunming Zhang, Jingwen Yu, Huirong Lin, Xin Pang, Yang Zhang, Heng Liu, Zainen Qin, Yi Cheng, Xiaoyong Wang, Wei Li, Xiangjian Kong, Xiaoyuan Chen and Gang Liu.* Zinc (II)‐Dipicolylamine Coordination Nanotheranostics: Toward Synergistic Nanomedicine by Combined Photo/Gene Therapy. Angewandte Chemie International Edition, 2019, 58(1): 269 –272.
16. Jing Zhu,# Chengchao Chu,# Dongsheng Li, Xin Pang, Huili Zheng, Junqing Wang, Yesi Shi, Yang Zhang, Yi Cheng, En Ren, Jingliang Cheng, Xiaoyuan Chen, Gang Liu.* Fe (III)‐Porphyrin Sonotheranostics: A Green Triple‐Regulated ROS Generation Nanoplatform for Enhanced Cancer Imaging and Therapy. Advanced Functional Materials, 2019, 29(36): 1904056.
17. Jun Zhang#, Yun Zeng#, Min Su#, Ming Yu#, Yang Zhang, Hongwei Cheng, Huili Zheng, Jianming Liu, Xiaoyong Wang, Zhao Lei, Chengchao Chu*, Gang Liu*. MultifunctionalFerritin Nanoparticles as Theranostics for Imaging-guided Tumor Phototherapy. Journal ofBiomedical Nanotechnology, 2019, 15(7):1546-1555.
18. Chengchao Chu#, Min Su#, Jing Zhu#, Dongsheng Li, Hongwei Cheng, Junqing Wang, Xiaoyuan Chen and Gang Liu*. Metal-Organic Framework Nanoparticle-Based Biomineralization: A New Strategy toward Cancer Treatment. Theranostics, 2019; 9(11): 3134-3149.
19. Heng Liu,# Chengchao Chu,# Yu Liu,# Xin Pang, Yayun Wu, Zijian Zhou, Pengfei Zhang, Weiguo Zhang,* Gang Liu,* and Xiaoyuan Chen. Intra-polymerization Doped Manganese-eumelanin Coordination Nanocomposites with Ultrahigh Relaxivity for Tumor Theranostic Applications. Advanced Science, 2018, 5(7): 1800032.
20. Zhiyuan Shi#, Chengchao Chu#, Yang Zhang, Zhaojie Su, Huirong Lin, Xin Pang, Xiaoyong Wang, Gang Liu*, Wengang Li*. Self-Assembled Metal-Organic Nanoparticles for Multimodal Imaging-Guided Photothermal Therapy of Hepatocellular Carcinoma. Journal of Biomedical Nanotechnology, 2018, 14(11): 1934-1943.
21. Chao Huang#, Chengchao Chu#, Xiaoyong Wang, Huirong Lin, Junqing Wang, Yun Zeng, Wenzhen Zhu, Yi-Xiang J. Wang, Gang Liu*. Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy. Biomaterials Science, 2017, 5, 1512-1516.
22. Chengchao Chu#, Shengxiang Ge#, Jing Zhang, Huirong Lin, Gang Liu*, Xiaoyuan Chen. Enzyme-free colorimetric determination of EV71 virus using a 3D-MnO2-PEG nanoflower and 4-MBA-MA-AgNPs. Nanoscale, 2016, 8(36), 16168-16171.
23. Chengchao Chu, Lei Shen, Shenguang Ge, Lei Ge, Jinghua Yu, Mei Yan*, Xianrang Song. Using“dioscorea batatas bean”-like silver nanoparticles based localized surface plasmon resonance to enhance the fluorescent signal of zinc oxide quantum dots in a DNA sensor. Biosensors and Bioelectronics, 2014, 61, 344-350.
24. Chengchao Chu, Meng Li, Shenguang Ge, Lei Ge, Jinghua Yu, Mei Yan*, Xianrang Song, Long Li, Baohai Han, Jianxiu Li. “Sugarcoated haws on a stick”-like MWNTs@Fe3O4@C coaxial nanomaterial: synthesis, characterization and application in electrochemiluminescence immunoassays. Biosensors and Bioelectronics, 2013, 47, 68-74.
25. Chengchao Chu, Long Li, Shuai Li, Meng Li, Shenguang Ge, Jinghua Yu, Mei Yan*, Xianrang Song. Fluorescence-based immunoassay for human chorionic gonadotropin based on polyfluorene-coated silica nanoparticles and polyaniline-coated Fe3O4 nanoparticles. Microchim Acta, 2013, 180:1509–1516.
26. Chengchao Chu, Meng Li, Long Li, Shenguang Ge, Lei Ge, Jinghua Yu, Mei Yan*, Xianrang Song. Preparation of Fe3O4@C@CNC multifunctional magnetic core/shell nanoparticles and their application in a signal-type flow-injection photoluminescence immunosensor. Analytical and Bioanalytical Chemistry, 2013, 405, 9555-9561.
27. Chengchao Chu, Xiu Wang, Shuai Li, Shenguang Ge, Lei Ge, Jinghua Yu, Mei Yan*. Synthesis, characterization of a novel phenyleneethynylene derivative and application in a fluorescence DNA sensor. Analytical Methods, 2012, 4, 4339-4345.
