研究领域

细胞死亡是生命体的基本属性，在成体发育、稳态维持以及疾病等过程中发挥重要作用。我们的研究主要是为了阐明细胞坏死样凋亡和焦亡的分子机制以及理解细胞死亡在生理病理情况下扮演的角色。另外，我们也采用光学成像，尤其是超高分辨率显微成像技术探索感兴趣的生物医学相关的科学问题。

学习经历

2006年，皇冠，生命科学学院，学士

2011年，中国科学院生物化学与细胞生物学研究所，博士

工作经历

2011-2018年，皇冠，生命科学学院，博士后

2018年至今，皇冠，生命科学学院，副教授

代表性成果

1. Xue Z, Wang S, Li J, Chen X*, Han J, Han S*. A Bifunctional Super-resolution Imaging Probe with Acidity-independent Lysosome-retention Mechanism. Anal Chem. 2018 Aug 27. doi: 10.1021/acs.analchem.8b02365.
2. Gao H, Yang Z, Wang X, Qian P, Hong R, Chen X, Su XZ, Cui H, Yuan J*. ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility. Curr Biol. 2018 Aug 17. pii: S0960-9822(18)30860-1. doi: 10.1016/j.cub.2018.06.069.
3. Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J*. RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis. Nat Cell Biol. 2018 Feb;20(2):186-197. doi: 10.1038/s41556-017-0022-y.
4. Zhang Y, Chen X, Gueydan C, Han J*. Plasma membrane changes during programmed cell deaths. Cell Res. 2018 Jan;28(1):9-21. doi: 10.1038/cr.2017.133.
5. Zhang Y#, Su SS#, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J*. RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome. Nat Commun. 2017 Feb 8;8:14329. doi: 10.1038/ncomms14329.
6. Huang D, Zheng X, Wang ZA, Chen X, He WT, Zhang Y, Xu JG, Zhao H, Shi W, Wang X, Zhu Y, Han J*. MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process. Mol Cell Biol. 2017 Feb 15;37(5). pii: e00497-16. doi: 10.1128/MCB.00497-16.
7. Chen X#, He WT#, Hu L, Li J, Fang Y, Wang X, Xu X, Wang Z, Huang K, Han J*. Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis. Cell Res. 2016 Sep;26(9):1007-20. doi: 10.1038/cr.2016.100.
8. Wu XN#, Yang ZH#, Wang XK, Zhang Y, Wan H, Song Y, Chen X, Shao J, Han J*. Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis. Cell Death Differ. 2014 Nov;21(11):1709-20. doi: 10.1038/cdd.2014.77.
9. Chen X#, Li W#, Ren J#, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J*. Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res. 2014 Jan;24(1):105-21. doi: 10.1038/cr.2013.171. (Highlighted in Cell Res and selected by Faculty of 1000 Biology)
10. Chen X#, Ma JJ#, Tan M, Yao P, Hu QH, Eriani G, Wang ED*. Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase. Nucleic Acids Res. 2011 Jan;39(1):235-47. doi: 10.1093/nar/gkq763.
Last updated 2018/09/07