郑启凡 助理教授/硕导 学科（方向）：医学免疫学/肿瘤免疫 所在系部：基础医学部 办公电话：0592-2880599 邮    箱：zhengqf@xmu.edu.cn

研究领域：

郑启凡博士主要开展肿瘤及免疫细胞分化的表观遗传学研究，聚焦肿瘤发生发展的组蛋白修饰以及肿瘤免疫中的表观遗传学修饰分子机制。近几年的研究证实了表观调控因子menin通过印迹非依赖途径促进肝细胞肝癌IGF2基因的表达，进而导致肝细胞肝癌恶性进展的表观遗传学分子机制；阐明了TrxG与PcG家族成员在单核细胞向巨噬细胞的分化及功能活化中的重要生物学功能及其表观遗传学机制等。部分研究成果发表在BBA-Gene Regulatory Mechanisms, FEBS J等SCI杂志。

学习经历：

2005～2013 哈尔滨医科大学基础医学八年制 医学博士

工作经历：

2014～2015 皇冠hg0086客户端 科研实习；

2015～2017 皇冠生物学博士后流动站 博士后；

2017～至今 皇冠hg0086客户端 助理教授；

代表性成果：

1. Zheng QF^#, Xu B^#*, Wang HM, Ding LH, Liu JY, Zhu LY, Qiu H, Zhang L, Ni GY, Ye J, Gao SB and Jin GH*. Epigenetic alterations contribute to promoter activity of imprinting gene IGF2. BBA -Gene Regulatory Mechanisms. 2018,1861(2):117-124；

2. Zheng QF^#, Wang HM^#, Wang ZF, Liu JY, Zhang Q, Zhang L, Lu YH, You H and Jin GH*. Reprogramming of histone methylation controls the differentiation of monocytes into macrophages. The FEBS Journal. 2017,284(9):1309-1323;

3. Zheng QF^#, Han L^#, Dong YC^#, Tian J, Huang W, Liu ZY, Jia XZ, Jiang T, Zhang JN, Li X*, Kang CS*, Ren H*. JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2 /STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma. Neuro-Oncology. 2014,16(9):1229-1243;

4. Gao SB, Zheng QF, Xu B, Pan CB, Li KL, Zhao Y, Zheng QL, Lin X, Xue LX and Jin GH*. EZH2 represses target genes through H3K27-dependent and H3K27-independent mechanisms in hepatocellular carcinoma. Molecular Cancer Research. 2014, 12: 1388-1397;

5. Gao SB^#, Xu B^#, Ding LH, Zheng QL, Zhang L, Zheng QF, Li SH, Feng ZJ, Wei J, Yin ZY, Hua X, Jin GH*. The functional and mechanistic relatedness of the EZH2 and menin in hepatocellular carcinoma. Journal of Hepatology. 2014, 61(4): 832-839;

6. Hu MH, Zheng QF, Jia XZ, Li Y, Dong YC, Wang CY, Lin QY, Zhang FY, Zhao RB, Xu HW, Zhou JH, Yuan HP, Zhang WH, Ren H*. Neuroprotection effect of interleukin (IL)-17 secreted by reactive astrocytes is emerged from a high-level IL-17-containing environment during acute neuroinflammation. Clin Exp Immunol. 2014, 175(2): 268-284;

7. Li X^#*, Wang Q^#, Zheng Y^#, Lv S, Ning S, Sun J, Huang T, Zheng Q, Ren H, Xu J, Wang X, Li Y*. Prioritizing human cancer microRNAs based on genes' functional consistency between microRNA and cancer. Nucleic Acids Research. 2011, 39(22):e153.

主持过的重要课题：

1. 国家自然科学基金青年科学基金项目，81502444，肝癌中印记基因IGF2转录激活的H3K4组蛋白甲基化修饰机制，2016/01-2018/12，18万元，在研，主持；

2. 中国博士后科学基金面上资助（一等），2015M580563，肝癌中组蛋白修饰调控IGF2转录激活的表观遗传学机制，2015/11-2017/03，8万元，已结题，主持。

所有论文列表：

1. Zheng QF^#, Xu B^#*, Wang HM, Ding LH, Liu JY, Zhu LY, Qiu H, Zhang L, Ni GY, Ye J, Gao SB and Jin GH*. Epigenetic alterations contribute to promoter activity of imprinting gene IGF2. BBA -Gene Regulatory Mechanisms. 2018,1861(2):117-124 DOI:10.1016/j.bbagrm.2017.12.007 PMID: 29413895

2. Zheng QF^#, Wang HM^#, Wang ZF, Liu JY, Zhang Q, Zhang L, Lu YH, You H and Jin GH*. Reprogramming of histone methylation controls the differentiation of monocytes into macrophages. The FEBS Journal. 2017,284(9):1309-1323 DOI: 10.1111/febs.14060 PMID: 28304152

3. Zheng QF^#, Han L^#, Dong YC^#, Tian J, Huang W, Liu ZY, Jia XZ, Jiang T, Zhang JN, Li X*, Kang CS*, Ren H*. JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2 /STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma. Neuro-Oncology. 2014,16(9):1229-1243 DOI: 10.1093/neuonc/nou046 PMID: 24861878 PMCID: PMC4136898

4. Gao SB, Zheng QF, Xu B, Pan CB, Li KL, Zhao Y, Zheng QL, Lin X, Xue LX and Jin GH*. EZH2 represses target genes through H3K27-dependent and H3K27-independent mechanisms in hepatocellular carcinoma. Molecular Cancer Research. 2014, 12: 1388-1397 DOI: 10.1158/1541-7786.MCR-14-0034 PMID: 24916103

5. Gao SB^#, Xu B^#, Ding LH, Zheng QL, Zhang L, Zheng QF, Li SH, Feng ZJ, Wei J, Yin ZY, Hua X, Jin GH*. The functional and mechanistic relatedness of the EZH2 and menin in hepatocellular carcinoma. Journal of Hepatology. 2014, 61(4): 832-839 DOI: 10.1016/j.jhep.2014.05.015 PMID: 24845612

6. Hu MH, Zheng QF, Jia XZ, Li Y, Dong YC, Wang CY, Lin QY, Zhang FY, Zhao RB, Xu HW, Zhou JH, Yuan HP, Zhang WH, Ren H*. Neuroprotection effect of interleukin (IL)-17 secreted by reactive astrocytes is emerged from a high-level IL-17-containing environment during acute neuroinflammation. Clin Exp Immunol. 2014, 175(2): 268-284 DOI: 10.1111/cei.12219 PMID: 24117055 PMCID: PMC3892418

7. Li X^#*, Wang Q^#, Zheng Y^#, Lv S, Ning S, Sun J, Huang T, Zheng Q, Ren H, Xu J, Wang X, Li Y*. Prioritizing human cancer microRNAs based on genes' functional consistency between microRNA and cancer. Nucleic Acids Research. 2011, 39(22):e153 DOI: 10.1093/nar/gkr770 PMID: 21976726 PMCID: PMC3239203