张洪峰 助理教授

研究方向：儿童遗传性脑病

所在系部：神经科学研究所

邮    箱：hongfeng_zhang@xmu.edu.cn

系部网址：https://neuro.xmu.edu.cn

主要研究领域：

遗传性小脑共济失调、唐氏（21三体）综合征等儿童遗传性脑病的发病机制和治疗研究。

学习经历：

2013-2016 北京大学基础皇冠神经生物学专业 博士

2010-2013 中南大学药学院药理专业 硕士

2006-2010 西北农林科技大学生命学院生物科学专业 学士

工作经历：

2019-至今 皇冠hg0086客户端 助理教授

2016-2019 皇冠hg0086客户端 博士后

(1)Zhang HF^#, Hong Y^#, Yang W, Wang R, Yao T, Wang J, Liu K, Yuan H, Xu C, Zhou Y, Li G, Zhang L, Luo H, Zhang X, Du D, Sun H, Zheng Q, Zhang Y-W, Zhao Y, Zhou Y, Xu H, Wang X*. SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate. National Science Review, 2021. 8. nwab024.

(2) Zhang HF^#, Zhu L^#, Wang F^#, Wang R, Hong Y, Chen Y, Zhu B, Gao Y, Luo H, Zhang X, Sun H, Zhou Y*, Yao Y*, Wang X*. Novel KCNJ10 Compound Heterozygous Mutations Causing EAST/SeSAME-Like Syndrome Compromise Potassium Channel Function. Frontiers in genetics, 2019, 10: 0-912.

(3) Dai YC^#, Zhang HF^#, Schon M, Boeckers TM, Han, SP, Han JS, Zhang R*. (2018). Neonatal Oxytocin Treatment Ameliorates Autistic-Like Behaviors and Oxytocin Deficiency in Valproic Acid-Induced Rat Model of Autism. Frontiers in Cellular Neuroscience, 2018. 12: p. 355.

(4) Zhang HF^#, Huang T, Hong Y, Yang W, Zhang X, Luo H, Xu H, Wang X. The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases. Frontiers in Aging Neuroscience, 2018. 10: p. 79.

(5) Zhang R#*, Zhang HF^#, Han JS, Han SP. Genes Related to Oxytocin and Arginine-Vasopressin Pathways: Associations with Autism Spectrum Disorders. Neuroscience Bulletin, 2017. 33(2): p. 238-246.

(6) Zhang HF^#, Dai YC, Wu J, Jia MX, Zhang JS, Shou XJ, Han SP, Zhang R*, Han JS*. Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms. Neuroscience Bulletin, 2016. 32(5): p. 423-32.

(7) Zheng Q^#, Li G^#, Wang S, Zhou Y, Liu K, Gao Y, Zhou Y, Zheng L, Zhu L, Deng Q, Wu M, Di A, Zhang L, Zhao Y, Zhang HF, Sun H, Dong C, Xu H, Wang X*. Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25. Science Advances. 2021;7(1): eabe1340.

(8) Zeng F^#, Ma X^#, Zhu L^#, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang HF, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, and Wang X*. The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability. PLoS Biology. 2019;17(12): e3000525.

主持课题：

（1）国家自然科学青年科学基金（81701349），20万元，结题

（2）中国博士后科学基金（一等）（2016M600502），8万元，结题

获奖及荣誉

（1）2018年Neuroscience bulletin杂志优秀论文特等奖（第1作者）

所有文章链接：https://www.researchgate.net/profile/Hong-Feng-Zhang