胡皎月 助理教授/硕士生导师 学科（方向）：眼科学/眼表与角膜病的临床与研究所在系部：眼科研究所 邮 箱：mydear_22000@163.com |  |
研究领域
从事眼表与角膜病的临床与研究工作，熟悉眼表常见疾病的诊疗。主要研究领域为：干眼、眼表免疫、糖尿病眼表病变等。
学习经历
1998~2003，北京大学医学部临床医学专业，医学学士；
2003~2006，中山医科大学眼科中心眼科学专业，医学硕士；
2009~2012，皇冠hg0086客户端生理学专业，理学博士
工作经历
2006~2013，皇冠hg0086客户端，助理实验师、实验师；
2017~2018, 美国baylor皇冠，博士后；
2013~至今，皇冠hg0086客户端，助理教授
主持的科研课题
1.国家自然科学基金联合基金项目区域创新发展联合基金（子课题负责人），低温环境下lncRNA甲基化对干眼免疫性炎症的影响及其调控机制，U20A20363，2021-2024，50万（总经费260万）
2.皇冠新型冠状病毒防治应急科研攻关项目，新型冠状病毒性角结膜炎的感染、潜伏、复发的机制研究，20720200023，2020.02-2020.12，30万
3.Lions Foundation for Sight（LFFS）,USA. Explore new phenotypes of human limbal epithelial stem cells by single-cell transcriptomics, 2018.06-2019.06，1万美元
4.国家自然科学基金青年基金，SERPINA3K抑制角膜缘微环境功能障碍及其机制研究，81100638，2012-2014，22万元
代表性成果：
1.Shaopan Wang, Xin He, Qingmin Li, Yuhan Zhang, Jiaoyue Hu, Rongrong Zong, Jingyi Zhuang, Andrew J Quantock, Yingying Gao, Wei Li, Zuguo Liu. Obstructive sleep apnea affects lacrimal gland function, Invest Ophthalmol Vis Sci. 2022 Mar 2;63(3):3.
2.Jin-Miao Li, Sangbae Kim, Yun Zhang, Fang Bian, Jiaoyue Hu, Rong Lu, Stephen Pflugfelder, Rui Chen, and Dequan Li. Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus, Invest Ophthalmol Vis Sci. 2021 Jul 1;62(9):36.
3.Cheng X, He D, Liao C, Lin S, Tang L, Wang YL, Hu J, Li W, Liu Z, Wu Y, Liao Y. IL-1/IL-1R signaling induced by all-trans-retinal contributes to complement alternative pathway activation in retinal pigment epithelium, J Cell Physiol. (Journal of Cellular Physiology), 2021 May;236(5):3660-3674.
4.Weijie Ouyang, Yang Wu, Xiang Lin, Shoubi Wang, Yiran Yang, Liying Tang, Zhaolin Liu, Jieli Wu, Caihong Huang, Yueping Zhou, Xiaobo Zhang, Jiaoyue Hu* (Co-Correspanding) and Zuguo Liu*. Role of CD4+ T helper cells in the development of BAC-induced dry eye syndrome in mice, Invest Ophthalmol Vis Sci. 2021 Jan 4;62(1):25.
5.De-Quan Li; Sangbae Kim; Jinmiao Li; Qianmiao Gao; Jongsu Choi; Fang Bian; Jiaoyue Hu; Yun Zhang; Jin Li; Rong Lu; Yumei Li; Stephen C. Pflugfelder; Hongyu Miao; Rui Chen. Single-Cell Transcriptomics Identifies Limbal Stem Cells Population and Cell Types Mapping Its Differentiation Trajectory in Limbal Basal Epithelium of Human Cornea, the Ocular Surface, 2021 Jan 1;20:20-32.
6.Xiang Lin, Yang Wu, Liying Tang, Weijie Ouyang, Yiran Yang, Zhaolin Liu, Jieli Wu, Xiaoxiang Zheng, Caihong Huang, Yueping Zhou, Xiaobo Zhang, Yongxiong Chen, Wei Li, Jiaoyue Hu* (Correspanding) and Zuguo Liu. Comparison of Treatment Effect and Tolerance of the Topical Application of Mizoribine and Cyclosporine A in a Mouse Dry Eye Model, Transl Vis Sci Technol. (Translational Vision Science & Technology), 2020 Dec 15;9(13):22.
7.Liu Z, Jin M, Li Y, Liu J, Xiao X, Bi H, Pan Z, Shi H, Xie X, Zhang M, Gao X, Li L, Ouyang W, Tang L, Wu J, Yang Y, Hu J, Liu Z, Efficacy and Safety of Houttuynia Eye Drops Atomization Treatment for Meibomian Gland Dysfunction-Related Dry Eye Disease: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. J Clin Med (Journal of Clinical Medicine), 2020 Dec 12;9(12):E4022.
8. Jiaoyue Hu, Ning Gao, Yun Zhang, Xin Chen, Jinmiao Li, FangBian, Wei Chi, Zuguo Liu, Cintia de Paiva, Stephen C. Pflugfelder and De-Quan Li. IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation, Mucosal Immunology, 2020 Nov;13(6):919-930,
9.Ruzhi Deng, Xin Chen, Yun Zhang, Fang Bian, Ning Gao, Jiaoyue Hu, Changjun Wang, Rodrigo G. de Souza, Fan Lu, Stephen C. Pflugfelder and De-Quan Li. Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation, Mucosal Immunology, 2019 Sep;12(5):1141-1149.
获奖：
1.2011 ARVO travel grant: The Corneal Morphological Changes by in vivo Confocal Microscopy Reveal Early Toxic Signs Induced by Benzalkonium Chloride.
2.The 116th Annual Meeting of the Japanese Ophthalmological Society travel grant (2012 JOS): SERPINA3K protects rabbit corneal endothelium from barrier function disruption.
