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临床教师(教授、副教授)

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任建林

发布时间： 2022年06月01日浏览次数：

任建林 教授、博士生导师

福建省“闽江学者”特聘教授

研究方向：胃肠微生态及胃肠道肿瘤早诊早治办公电话：0592-2591051

邮箱：renjianl@xmu.edu.cn

个人简介

任建林，闽江学者特聘教授、主任医师、西安交通大学医学博士、博士生/博士后合作导师、国家卫生健康突出贡献中青年专家、享受国务院政府特殊津贴专家，国家临床重点专科消化内科带头人，纽约大学、哈佛大学麻省总院访问医师。

现任皇冠附属中山医院副院长、皇冠消化疾病研究所所长、皇冠hg0086客户端微生态研究院院长、皇冠hg0086客户端消化病学系主任、厦门市肠道微生态与健康重点实验室主任、厦门市消化内镜质控中心主任。

兼任中国医师协会消化医师分会常务委员、中国医师协会内镜医师分会常务委员、中华医学会消化病学分会委员兼副秘书长，海峡两岸医药卫生交流协会常务理事兼消化病学分会候任主任委员、海峡两岸医药卫生交流协会消化内镜学分会副主任委员、中国医学国际交流促进会消化病学分会副主任委员兼微生态学组组长、中国医师协会内镜人工智能委员会副主任委员、中国科技产业促进会微生态医疗专家委员会常务副主任委员、国家卫健委消化内镜质控专家委员、国家教育部高校临床实践指导委员会委员、白求恩基金会消化病学分会常务委员、福建省医学会消化病学分会副主任委员、福建省医师协会消化医师分会副主任委员、厦门市医学会消化病学分会前任主任委员、厦门市医师协会消化医师分会主任委员。获评福建省高层次人才、福建省百千万人才、厦门市杰出人才、厦门市拔尖人才、厦门市领军特支人才、厦门卫生系统首批学术与技术带头人。

牵头创建了海峡两岸消化论坛暨世界华人消化高峰论坛、世界华人消化青年论坛、海峡消化中华行等知名学术品牌。是国家科技奖评审专家、中华医学科技奖评审专家、国家科技重大专项评审专家、教育部长江学者特聘教授评审专家。担任全国高等皇冠校规划教材《内科学》常务编委，主编专著10部，SCI收录论文60余篇,包括: Lancet gastroenterolgy & hepatology、Gastroenterolgy、J Hepatology、Hepatology 等，主持973、国家科技重大专项分课题5项、国家自然科学基金4项，省、市重大课题10余项，获科技奖6项，其中第一完成人福建省科技进步二等奖1项及厦门市科技进步1等奖1项，获批转化各类专利7项，培养硕士、博士、博士后115名，是《Journal Digestive Disease》、《中华消化杂志》、《中华胰腺病杂志》等杂志编委，是海峡两岸消化杰出贡献奖获得者、福建省卫生健康系统先进工作者。

所率领的团队获评福建省优秀导师团队，在肠道微生态与消化重大疾病防治、医学人工智能产学研转化应用，消化系肿瘤早诊早治等领域处于国内先进水平。

研究领域

主要从事医学消化病学临床实践、科学研究及教育教学工作。长期从事消化疑难病诊治，擅长消化道粘膜损伤与保护，消化系早癌防治，消化身心疾病诊治，肠道微生态、医学人工智能内镜临床应用研发等相关工作。

学习经历

1994-1997西安医科大学内科学硕士

2001-2004西安交通大学皇冠内科学博士

工作经历

1997.07-1999.12，皇冠附属中山医院主治医师

1999.12-2005.07，皇冠附属中山医院副主任医师

2005.07-至今，皇冠附属中山医院主任医师

2006.06-至今，皇冠附属中山医院博士后合作导师

2008.05-至今，皇冠hg0086客户端教授

代表性成果

	1.Shi Y#, Chen GB#, Huang QW#, Chen X, Liu JJ, Xu W, Liu YP, Xiao CX, Ren JL* (corresponding) and Guleng B*. miR218-5p regulates the proliferation of gastric cancer cells by targeting TFF1 in an Erk1/2-dependent manner. BBA - Molecular Basis of Disease. 2015, doi: 10.1016. (IF:5.089)
	2.Liu JJ#, Wang X#, Yang XN, Liu YP, Shi Y, Ren JL(corresponding) and Guleng B. miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells. Cancer Lett. 347(1):98-104, 2014.(IF:5.016)
	3.Wang HH#, Xie NN, Li QY, Hu YQ, Ren JL(corresponding) and Guleng B. Exome sequencing revealed novel germline mutations in Chinese Peutz-Jeghers syndrome patients. Dig Dis Sci. 59(1):64-71, 2014.
	4.Xiao L#, Liu YP#, Xiao CX#, Ren JL(corresponding)and Guleng B. Serum TFF3 may be a pharamcodynamic marker of responses to chemotherapy in gastrointestinal cancers. BMC Clin Pathol. 2014, doi: 10.1186.
	5.Yang XN#, Lu YP#, Liu JJ, Huang JK, Liu YP, Xiao CX, Jazag A, Ren JL(corresponding) and Guleng B. Piezo1 is as a novel trefoil factor family 1 binding protein that promotes gastric cancer cell mobility in vitro. Dig Dis Sci. 59(7):1428-35, 2014.
	6.Li P#, Xiao L, Li YY, Chen X, Xiao CX, Liu JJ, Yang XN, Jazag A, Ren JL(corresponding) and Guleng B. Fibrinogen Alpha Chain Acts as a HBsAg Binding Protein and their Interaction Promotes HepG2 Cell Apoptosis. Current Proteomics. 11:48-54, 2014.
	7.Xiao CX#, Yang XN#, Huang QW, Liu JJ, Liu YP, Jazag A, Guleng B* and Ren JL*(corresponding). ECHS1 acts as a novel HBsAg binding protein and its interaction enhances apoptosis through mitochondrial pathway in HepG2 cells. Cancer letter. 330(1):67-73, 2013. (IF:5.016)
	8.Zhang YQ#, Xiao CX#, Lin BY, Shi Y, Liu YP, Liu JJ, Guleng B, Ren JL(corresponding). Silencing of Pokemon enhances caspase-dependent apoptosis via fas- and mitochondria-mediated pathways in hepatocellular carcinoma cells. PLoS One. 17; 8(7):e68981, 2013.
	9.Wang LY#, Liu YP#, Chen LG, Chen YL, Tan L, Liu JJ, Jazag A, Ren JL(corresponding), Guleng B. Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells. PLoS One. 28; 8(6):e67542, 2013.
	10.Xiao CX#, Wang HH#, Shi Y, Li P, Liu YP, Ren JL(corresponding) and Guleng B. Distribution of bone-marrow-derived endothelial and immune cells in a murine colitis-associated colorectal cancer model. PLoS One. 8(9):e73666, 2013.
	11.Lin CC#, Zhou JP#, Liu YP, Liu JJ, Yang XN, Jazag A, Zhang ZP, Guleng B* and Ren JL*(corresponding).The Silencing of pokemon attenuates the proliferation of hepatocellular carcinoma cells in vitro and in vivo by Inhibiting the PI3K/Akt Pathway. PLoS One. 7(12):e51916, 2012.
	12.Liu JJ#, Wang X#, Cai YL, Zhou JP, Guleng B, Shi HX and Ren JL*(corresponding). The regulation of trefoil factor 2 expression by the transcription factor Sp3. Biochem Bioph Res Co. 427:410-414, 2012.
	13.Liu YP#, Yang XN#, Jazag A, Pan JS, Hu TH, Liu JJ, Guleng B* and Ren JL*(corresponding). HBsAg inhibits the translocation of JTB into mitochondria in HepG2 cells and potentially plays a role in HCC progression. PLoS One. 7(5):e36914, 2012.
	14.Tang HL#, Hu YQ#, Qin XP, Jazag A, Yang H, Yang YX, Yang XN, Liu JJ, Chen JM, Guleng B, Ren JL(corresponding). Aplasia ras homolog member I is down regulated in gastric cancer and silencing its expression promotes cell growth in vitro. J Gastroenterol Hepato. 27 (8):1395-1404, 2012.
	15.Guleng B#, Han J, Yang JQ, Huang QW, Huang JK, Yang XN, Liu JJ, Ren JL*(corresponding). TFF3 mediated induction of VEGF via hypoxia in human gastric cancer SGC-7901 cells. Molecular Biology Reports. 39:4127-4134, 2012.
	16.Otsuka M#, Kang YJ, Ren J, Jiang H, Wang Y, Omata M, Han J*. Distinct effects of p38 alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease. Gastroenterology. 138(4):1237-9, 2010.
	17.Pan JS#, Zhang ZP#, Cai JY, Dong J, Ren J(corresponding) and Wang, XZ. Competitive priming PCR: a versatile method to generate cohesive terminus，Molecular Biology Reports. 37(3):1421-1425, 2010.
	18.Guleng B，Lian YM，Ren J(corresponding). Mindin is upregulated during colitis and may activate NF-kappa B in a TLR-9 mediated manner. World Journal of Gastroenterology. 16(9):1070-1075, 2010.

承担的重要课题

1. 国家自然科学基金面上项目，81370591，《miRNA423-5p调控三叶因子表达及在胃肠道粘膜修复中的作用机制》，2014.01-2017.12

2. 国家自然科学基金面上项目，30971362，《TFF3结合蛋白的验证及其介导胃癌细胞转移侵袭机制研究》，2010.01-2012.12

3. 国家自然科学基金委主任项目，30750013，《三叶因子3 与胃癌转移、侵袭的机制》，2008.01-2008.12

4. 国家重大科学研究计划子课题，2013CB944903，《肝脏免疫前体细胞命运决定与分化的分子调控网络》，2013.1-2015.12

5. “973”计划子课题，2009CB522200，《炎症反应的细胞信号转导网络与肿瘤的关系》，2010.01-2013.12

6. 厦门市重要重大疾病联合攻关项目，3502Z20149032，《厦门市消化系统肿瘤早诊早治防控体系建设》，2014.01-2017.12

获奖及荣誉

2014年厦门市科学技术进步奖一等奖，乙型肝炎病毒新变异及临床治疗预测的研究

	1.Shi Y#, Chen GB#, Huang QW#, Chen X, Liu JJ, Xu W, Liu YP, Xiao CX, Ren JL* (corresponding) and Guleng B*. miR218-5p regulates the proliferation of gastric cancer cells by targeting TFF1 in an Erk1/2-dependent manner. BBA - Molecular Basis of Disease. 2015, doi: 10.1016. (IF:5.089)
	2.Liu JJ#, Wang X#, Yang XN, Liu YP, Shi Y, Ren JL(corresponding) and Guleng B. miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells. Cancer Lett. 347(1):98-104, 2014.(IF:5.016)
	3.Wang HH#, Xie NN, Li QY, Hu YQ, Ren JL(corresponding) and Guleng B. Exome sequencing revealed novel germline mutations in Chinese Peutz-Jeghers syndrome patients. Dig Dis Sci. 59(1):64-71, 2014.
	4.Xiao L#, Liu YP#, Xiao CX#, Ren JL(corresponding)and Guleng B. Serum TFF3 may be a pharamcodynamic marker of responses to chemotherapy in gastrointestinal cancers. BMC Clin Pathol. 2014, doi: 10.1186.
	5.Yang XN#, Lu YP#, Liu JJ, Huang JK, Liu YP, Xiao CX, Jazag A, Ren JL(corresponding) and Guleng B. Piezo1 is as a novel trefoil factor family 1 binding protein that promotes gastric cancer cell mobility in vitro. Dig Dis Sci. 59(7):1428-35, 2014.
	6.Li P#, Xiao L, Li YY, Chen X, Xiao CX, Liu JJ, Yang XN, Jazag A, Ren JL(corresponding) and Guleng B. Fibrinogen Alpha Chain Acts as a HBsAg Binding Protein and their Interaction Promotes HepG2 Cell Apoptosis. Current Proteomics. 11:48-54, 2014.
	7.Xiao CX#, Yang XN#, Huang QW, Liu JJ, Liu YP, Jazag A, Guleng B* and Ren JL*(corresponding). ECHS1 acts as a novel HBsAg binding protein and its interaction enhances apoptosis through mitochondrial pathway in HepG2 cells. Cancer letter. 330(1):67-73, 2013. (IF:5.016)
	8.Zhang YQ#, Xiao CX#, Lin BY, Shi Y, Liu YP, Liu JJ, Guleng B, Ren JL(corresponding). Silencing of Pokemon enhances caspase-dependent apoptosis via fas- and mitochondria-mediated pathways in hepatocellular carcinoma cells. PLoS One. 17; 8(7):e68981, 2013.
	9.Wang LY#, Liu YP#, Chen LG, Chen YL, Tan L, Liu JJ, Jazag A, Ren JL(corresponding), Guleng B. Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells. PLoS One. 28; 8(6):e67542, 2013.
	10.Xiao CX#, Wang HH#, Shi Y, Li P, Liu YP, Ren JL(corresponding) and Guleng B. Distribution of bone-marrow-derived endothelial and immune cells in a murine colitis-associated colorectal cancer model. PLoS One. 8(9):e73666, 2013.
	11.Lin CC#, Zhou JP#, Liu YP, Liu JJ, Yang XN, Jazag A, Zhang ZP, Guleng B* and Ren JL*(corresponding).The Silencing of pokemon attenuates the proliferation of hepatocellular carcinoma cells in vitro and in vivo by Inhibiting the PI3K/Akt Pathway. PLoS One. 7(12):e51916, 2012.
	12.Liu JJ#, Wang X#, Cai YL, Zhou JP, Guleng B, Shi HX and Ren JL*(corresponding). The regulation of trefoil factor 2 expression by the transcription factor Sp3. Biochem Bioph Res Co. 427:410-414, 2012.
	13.Liu YP#, Yang XN#, Jazag A, Pan JS, Hu TH, Liu JJ, Guleng B* and Ren JL*(corresponding). HBsAg inhibits the translocation of JTB into mitochondria in HepG2 cells and potentially plays a role in HCC progression. PLoS One. 7(5):e36914, 2012.
	14.Tang HL#, Hu YQ#, Qin XP, Jazag A, Yang H, Yang YX, Yang XN, Liu JJ, Chen JM, Guleng B, Ren JL(corresponding). Aplasia ras homolog member I is down regulated in gastric cancer and silencing its expression promotes cell growth in vitro. J Gastroenterol Hepato. 27 (8):1395-1404, 2012.
	15.Guleng B#, Han J, Yang JQ, Huang QW, Huang JK, Yang XN, Liu JJ, Ren JL*(corresponding). TFF3 mediated induction of VEGF via hypoxia in human gastric cancer SGC-7901 cells. Molecular Biology Reports. 39:4127-4134, 2012.
	16.Otsuka M#, Kang YJ, Ren J, Jiang H, Wang Y, Omata M, Han J*. Distinct effects of p38 alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease. Gastroenterology. 138(4):1237-9, 2010.
	17.Pan JS#, Zhang ZP#, Cai JY, Dong J, Ren J(corresponding) and Wang, XZ. Competitive priming PCR: a versatile method to generate cohesive terminus，Molecular Biology Reports. 37(3):1421-1425, 2010.
	18.Guleng B，Lian YM，Ren J(corresponding). Mindin is upregulated during colitis and may activate NF-kappa B in a TLR-9 mediated manner. World Journal of Gastroenterology. 16(9):1070-1075, 2010.